The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary...

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Autores principales: Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a6df162dc85447f4af921752869d12fa
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spelling oai:doaj.org-article:a6df162dc85447f4af921752869d12fa2021-12-02T14:40:57ZThe quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission10.1038/s41467-017-00981-y2041-1723https://doaj.org/article/a6df162dc85447f4af921752869d12fa2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00981-yhttps://doaj.org/toc/2041-1723Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures are variable.Vikas ChandraDalei WuSheng LiNalini PotluriYoungchang KimFraydoon RastinejadNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
description Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures are variable.
format article
author Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
author_facet Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
author_sort Vikas Chandra
title The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_short The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_full The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_fullStr The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_full_unstemmed The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_sort quaternary architecture of rarβ–rxrα heterodimer facilitates domain–domain signal transmission
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a6df162dc85447f4af921752869d12fa
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