Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearance of damaged lysosomes, and promotes inflammation....
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Nature Portfolio
2019
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oai:doaj.org-article:a6e1aa100a154ae9b970e162e6e98c2c2021-12-02T16:57:50ZGalectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease10.1038/s41467-019-11441-02041-1723https://doaj.org/article/a6e1aa100a154ae9b970e162e6e98c2c2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11441-0https://doaj.org/toc/2041-1723The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearance of damaged lysosomes, and promotes inflammation.Jian Jing SiewHui-Mei ChenHuan-Yuan ChenHung-Lin ChenChiung-Mei ChenBing-Wen SoongYih-Ru WuChing-Pang ChangYi-Chen ChanChun-Hung LinFu-Tong LiuYijuang ChernNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Jian Jing Siew Hui-Mei Chen Huan-Yuan Chen Hung-Lin Chen Chiung-Mei Chen Bing-Wen Soong Yih-Ru Wu Ching-Pang Chang Yi-Chen Chan Chun-Hung Lin Fu-Tong Liu Yijuang Chern Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| description |
The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearance of damaged lysosomes, and promotes inflammation. |
| format |
article |
| author |
Jian Jing Siew Hui-Mei Chen Huan-Yuan Chen Hung-Lin Chen Chiung-Mei Chen Bing-Wen Soong Yih-Ru Wu Ching-Pang Chang Yi-Chen Chan Chun-Hung Lin Fu-Tong Liu Yijuang Chern |
| author_facet |
Jian Jing Siew Hui-Mei Chen Huan-Yuan Chen Hung-Lin Chen Chiung-Mei Chen Bing-Wen Soong Yih-Ru Wu Ching-Pang Chang Yi-Chen Chan Chun-Hung Lin Fu-Tong Liu Yijuang Chern |
| author_sort |
Jian Jing Siew |
| title |
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| title_short |
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| title_full |
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| title_fullStr |
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| title_full_unstemmed |
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease |
| title_sort |
galectin-3 is required for the microglia-mediated brain inflammation in a model of huntington’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/a6e1aa100a154ae9b970e162e6e98c2c |
| work_keys_str_mv |
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