Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

Abstract Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PP...

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Autores principales:	Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wu, Menghuan Li, Zhong Luo
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cellular energy metabolism ferroptosis glucose glutamine Science Q
Acceso en línea:	https://doaj.org/article/a6e7e0dce0614942beeb23d05e584a5d
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spelling	oai:doaj.org-article:a6e7e0dce0614942beeb23d05e584a5d2021-11-17T08:40:31ZEmerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells2198-384410.1002/advs.202100997https://doaj.org/article/a6e7e0dce0614942beeb23d05e584a5d2021-11-01T00:00:00Zhttps://doi.org/10.1002/advs.202100997https://doaj.org/toc/2198-3844Abstract Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle are involved in the regulation of key ferroptosis markers such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH), and reactive oxygen species (ROS), therefore imposing potential regulatory roles in ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit ferroptosis for self‐preservation such as the upregulation of glycolysis and PPP. Due to the rapid proliferation of tumor cells and the intensified metabolic rate, tumor energy metabolism has become a target for disrupting the redox homeostasis and induce ferroptosis. Based on these emerging insights, regulatory impact of those‐tumor specific metabolic aberrations is systematically characterized, such as rewired glucose metabolism and metabolic compensation through glutamine utilization on ferroptosis and analyzed the underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies are also discussed by exploiting those metabolic vulnerabilities, which may open up new avenues for tumor treatment in a clinical context.Xuemei YaoWei LiDe FangChuyu XiaoXiao WuMenghuan LiZhong LuoWileyarticlecellular energy metabolismferroptosisglucoseglutamineScienceQENAdvanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cellular energy metabolism ferroptosis glucose glutamine Science Q
spellingShingle	cellular energy metabolism ferroptosis glucose glutamine Science Q Xuemei Yao Wei Li De Fang Chuyu Xiao Xiao Wu Menghuan Li Zhong Luo Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
description	Abstract Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle are involved in the regulation of key ferroptosis markers such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH), and reactive oxygen species (ROS), therefore imposing potential regulatory roles in ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit ferroptosis for self‐preservation such as the upregulation of glycolysis and PPP. Due to the rapid proliferation of tumor cells and the intensified metabolic rate, tumor energy metabolism has become a target for disrupting the redox homeostasis and induce ferroptosis. Based on these emerging insights, regulatory impact of those‐tumor specific metabolic aberrations is systematically characterized, such as rewired glucose metabolism and metabolic compensation through glutamine utilization on ferroptosis and analyzed the underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies are also discussed by exploiting those metabolic vulnerabilities, which may open up new avenues for tumor treatment in a clinical context.
format	article
author	Xuemei Yao Wei Li De Fang Chuyu Xiao Xiao Wu Menghuan Li Zhong Luo
author_facet	Xuemei Yao Wei Li De Fang Chuyu Xiao Xiao Wu Menghuan Li Zhong Luo
author_sort	Xuemei Yao
title	Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
title_short	Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
title_full	Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
title_fullStr	Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
title_full_unstemmed	Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
title_sort	emerging roles of energy metabolism in ferroptosis regulation of tumor cells
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a6e7e0dce0614942beeb23d05e584a5d
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_version_	1718425688399151104

Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

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