Supramolecular construction of a cyclobutane ring system with four different substituents in the solid state

Preparation of cyclobutanes with four different substituents is rare and often arduous. Here a cocrystallisation strategy enables the intermolecular [2+2] cross-photoreaction of non-symmetrical stilbene derivatives to obtain chiral tetrasubstituted cyclobutanes with up to four different substituents...

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Autores principales: Michael A. Sinnwell, Ryan H. Groeneman, Benjamin J. Ingenthron, Changan Li, Leonard R. MacGillivray
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a6ea5b35ee29422d87485a9e4518e741
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Sumario:Preparation of cyclobutanes with four different substituents is rare and often arduous. Here a cocrystallisation strategy enables the intermolecular [2+2] cross-photoreaction of non-symmetrical stilbene derivatives to obtain chiral tetrasubstituted cyclobutanes with up to four different substituents in quantitative yield.