Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hybrids

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Autores principales:	Shira Sagie, Shir Toubiana, Stella R. Hartono, Hagar Katzir, Aya Tzur-Gilat, Shany Havazelet, Claire Francastel, Guillaume Velasco, Frédéric Chédin, Sara Selig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f7
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spelling	oai:doaj.org-article:a6ea7685f09c4013935240ad88a3e9f72021-12-02T15:38:32ZTelomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids10.1038/ncomms140152041-1723https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f72017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14015https://doaj.org/toc/2041-1723ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hybridsShira SagieShir ToubianaStella R. HartonoHagar KatzirAya Tzur-GilatShany HavazeletClaire FrancastelGuillaume VelascoFrédéric ChédinSara SeligNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shira Sagie Shir Toubiana Stella R. Hartono Hagar Katzir Aya Tzur-Gilat Shany Havazelet Claire Francastel Guillaume Velasco Frédéric Chédin Sara Selig Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
description	ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hybrids
format	article
author	Shira Sagie Shir Toubiana Stella R. Hartono Hagar Katzir Aya Tzur-Gilat Shany Havazelet Claire Francastel Guillaume Velasco Frédéric Chédin Sara Selig
author_facet	Shira Sagie Shir Toubiana Stella R. Hartono Hagar Katzir Aya Tzur-Gilat Shany Havazelet Claire Francastel Guillaume Velasco Frédéric Chédin Sara Selig
author_sort	Shira Sagie
title	Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
title_short	Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
title_full	Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
title_fullStr	Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
title_full_unstemmed	Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids
title_sort	telomeres in icf syndrome cells are vulnerable to dna damage due to elevated dna:rna hybrids
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f7
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Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

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