Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI

Purpose: To probe the potential of apparent diffusion coefficient (ADC) to rectify the incidentally detected bone lesion on MRI into benign or malignant lesions. Materials and methods: We retrospectively recruited 44 patients (24 males and 20 females); with 52 bone lesions, who underwent diffusion w...

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Autores principales:	M.R. Nouh, Ahmed Doweidar, Abdullah Mohie-Eddin Khalil
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bone lesions Diffusion-weighted (DW) Apparent diffusion co-efficient (ADC) magnetic resonance imaging (MRI) 3 Tesla (3T) Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/a6eb6f0cf99c45ca9c160d32a6dc065e
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spelling	oai:doaj.org-article:a6eb6f0cf99c45ca9c160d32a6dc065e2021-11-26T04:31:18ZApparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI2352-047710.1016/j.ejro.2021.100386https://doaj.org/article/a6eb6f0cf99c45ca9c160d32a6dc065e2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352047721000666https://doaj.org/toc/2352-0477Purpose: To probe the potential of apparent diffusion coefficient (ADC) to rectify the incidentally detected bone lesion on MRI into benign or malignant lesions. Materials and methods: We retrospectively recruited 44 patients (24 males and 20 females); with 52 bone lesions, who underwent diffusion weighted (DW) imaging using multiple b-values on 3 T MRI. ADC maps were derived and analyzed by two radiologists; blinded to the final diagnosis. The mean ADC values were used for statistical analyses. The diagnosis was deduced by histopathological confirmation; in 32 lesions and strict clinical and imaging follow-up for at least 12 months; in 20 lesions. Results: The mean ADC value (mean±SD) of all malignant tumors (including cartilaginous neoplasms) was [0.92 ± 0.40] × 10ˉ3 mm2/s. This significantly differed from those of both primary benign tumors [1.14 ± 0.24] × 10ˉ3 mm2/s, (p = 0.011), and all non-malignant lesions collectively [1.29 ± 0.44] × 10ˉ3 mm2/s, (p < 0.001). Using mADC value of ≤ 1.1 × 10ˉ3 mm2/s resulted in 86.1% sensitivity and 62.5% speciﬁcity for characterizing a lesion as a malignant. The inter-rater reliability was almost perfect (95% CI = 0.954–0.985). Conclusion: ADC could be a non-invasive in-vivo surrogate that may be able to discern the incidentally discovered osseous lesions into benign and malignant pathologies and guide further diagnostic workup.M.R. NouhAhmed DoweidarAbdullah Mohie-Eddin KhalilElsevierarticleBone lesionsDiffusion-weighted (DW)Apparent diffusion co-efficient (ADC) magnetic resonance imaging (MRI)3 Tesla (3T)Medical physics. Medical radiology. Nuclear medicineR895-920ENEuropean Journal of Radiology Open, Vol 8, Iss , Pp 100386- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bone lesions Diffusion-weighted (DW) Apparent diffusion co-efficient (ADC) magnetic resonance imaging (MRI) 3 Tesla (3T) Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Bone lesions Diffusion-weighted (DW) Apparent diffusion co-efficient (ADC) magnetic resonance imaging (MRI) 3 Tesla (3T) Medical physics. Medical radiology. Nuclear medicine R895-920 M.R. Nouh Ahmed Doweidar Abdullah Mohie-Eddin Khalil Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
description	Purpose: To probe the potential of apparent diffusion coefficient (ADC) to rectify the incidentally detected bone lesion on MRI into benign or malignant lesions. Materials and methods: We retrospectively recruited 44 patients (24 males and 20 females); with 52 bone lesions, who underwent diffusion weighted (DW) imaging using multiple b-values on 3 T MRI. ADC maps were derived and analyzed by two radiologists; blinded to the final diagnosis. The mean ADC values were used for statistical analyses. The diagnosis was deduced by histopathological confirmation; in 32 lesions and strict clinical and imaging follow-up for at least 12 months; in 20 lesions. Results: The mean ADC value (mean±SD) of all malignant tumors (including cartilaginous neoplasms) was [0.92 ± 0.40] × 10ˉ3 mm2/s. This significantly differed from those of both primary benign tumors [1.14 ± 0.24] × 10ˉ3 mm2/s, (p = 0.011), and all non-malignant lesions collectively [1.29 ± 0.44] × 10ˉ3 mm2/s, (p < 0.001). Using mADC value of ≤ 1.1 × 10ˉ3 mm2/s resulted in 86.1% sensitivity and 62.5% speciﬁcity for characterizing a lesion as a malignant. The inter-rater reliability was almost perfect (95% CI = 0.954–0.985). Conclusion: ADC could be a non-invasive in-vivo surrogate that may be able to discern the incidentally discovered osseous lesions into benign and malignant pathologies and guide further diagnostic workup.
format	article
author	M.R. Nouh Ahmed Doweidar Abdullah Mohie-Eddin Khalil
author_facet	M.R. Nouh Ahmed Doweidar Abdullah Mohie-Eddin Khalil
author_sort	M.R. Nouh
title	Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
title_short	Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
title_full	Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
title_fullStr	Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
title_full_unstemmed	Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI
title_sort	apparent diffusion coefficient (adc): a potential in vivo biological surrogate of the incidentally discovered bone lesions at 3t mri
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a6eb6f0cf99c45ca9c160d32a6dc065e
work_keys_str_mv	AT mrnouh apparentdiffusioncoefficientadcapotentialinvivobiologicalsurrogateoftheincidentallydiscoveredbonelesionsat3tmri AT ahmeddoweidar apparentdiffusioncoefficientadcapotentialinvivobiologicalsurrogateoftheincidentallydiscoveredbonelesionsat3tmri AT abdullahmohieeddinkhalil apparentdiffusioncoefficientadcapotentialinvivobiologicalsurrogateoftheincidentallydiscoveredbonelesionsat3tmri
_version_	1718409859030843392

Apparent diffusion coefficient (ADC): A potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI

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