Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

Thawatchai Phaechamud,1 Sarun Tuntarawongsa2 1Department of Pharmaceutical Technology, 2Pharmaceutical Intelligence Unit Prachote Plengwittaya, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: Eutectic solvent can solubilize high amount of some therapeutic compounds. Vo...

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Autores principales:	Phaechamud T, Tuntarawongsa S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Eutectic emulsion solvent evaporation ibuprofen nanosuspension ultrasonication Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a6eb970479934dbca659b3ef3b98d523
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spelling	oai:doaj.org-article:a6eb970479934dbca659b3ef3b98d5232021-12-02T00:44:40ZTransformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique1178-2013https://doaj.org/article/a6eb970479934dbca659b3ef3b98d5232016-06-01T00:00:00Zhttps://www.dovepress.com/transformation-of-eutectic-emulsion-to-nanosuspension-fabricating-with-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Thawatchai Phaechamud,1 Sarun Tuntarawongsa2 1Department of Pharmaceutical Technology, 2Pharmaceutical Intelligence Unit Prachote Plengwittaya, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (Tg) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. Keywords: eutectic, emulsion solvent evaporation, ibuprofen, nanosuspension, ultrasonicationPhaechamud TTuntarawongsa SDove Medical PressarticleEutecticemulsion solvent evaporationibuprofennanosuspensionultrasonicationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2855-2865 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eutectic emulsion solvent evaporation ibuprofen nanosuspension ultrasonication Medicine (General) R5-920
spellingShingle	Eutectic emulsion solvent evaporation ibuprofen nanosuspension ultrasonication Medicine (General) R5-920 Phaechamud T Tuntarawongsa S Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
description	Thawatchai Phaechamud,1 Sarun Tuntarawongsa2 1Department of Pharmaceutical Technology, 2Pharmaceutical Intelligence Unit Prachote Plengwittaya, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand Abstract: Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (Tg) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. Keywords: eutectic, emulsion solvent evaporation, ibuprofen, nanosuspension, ultrasonication
format	article
author	Phaechamud T Tuntarawongsa S
author_facet	Phaechamud T Tuntarawongsa S
author_sort	Phaechamud T
title	Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
title_short	Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
title_full	Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
title_fullStr	Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
title_full_unstemmed	Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
title_sort	transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a6eb970479934dbca659b3ef3b98d523
work_keys_str_mv	AT phaechamudt transformationofeutecticemulsiontonanosuspensionfabricatingwithsolventevaporationandultrasonicationtechnique AT tuntarawongsas transformationofeutecticemulsiontonanosuspensionfabricatingwithsolventevaporationandultrasonicationtechnique
_version_	1718403517375315968

Transformation of eutectic emulsion to nanosuspension fabricating with solvent evaporation and ultrasonication technique

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