Methamphetamine inhibits antigen processing, presentation, and phagocytosis.

Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it is associated with a 2-fold higher risk for obtaining HIV and associated secondary infections. We re...

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Autores principales:	Zsolt Tallóczy, Jose Martinez, Danielle Joset, Yonaton Ray, Attila Gácser, Sima Toussi, Noboru Mizushima, Joshua D Nosanchuk, Harris Goldstein, John Loike, David Sulzer, Laura Santambrogio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a6eb9c55a95644e1bda78b25dd973a7b
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spelling	oai:doaj.org-article:a6eb9c55a95644e1bda78b25dd973a7b2021-11-25T05:46:44ZMethamphetamine inhibits antigen processing, presentation, and phagocytosis.1553-73661553-737410.1371/journal.ppat.0040028https://doaj.org/article/a6eb9c55a95644e1bda78b25dd973a7b2008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18282092/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it is associated with a 2-fold higher risk for obtaining HIV and associated secondary infections. We report the first specific evidence that Meth at pharmacological concentrations exerts a direct immunosuppressive effect on dendritic cells and macrophages. As a weak base, Meth collapses the pH gradient across acidic organelles, including lysosomes and associated autophagic organelles. This in turn inhibits receptor-mediated phagocytosis of antibody-coated particles, MHC class II antigen processing by the endosomal-lysosomal pathway, and antigen presentation to splenic T cells by dendritic cells. More importantly Meth facilitates intracellular replication and inhibits intracellular killing of Candida albicans and Cryptococcus neoformans, two major AIDS-related pathogens. Meth exerts previously unreported direct immunosuppressive effects that contribute to increased risk of infection and exacerbate AIDS pathology.Zsolt TallóczyJose MartinezDanielle JosetYonaton RayAttila GácserSima ToussiNoboru MizushimaJoshua D NosanchukHarris GoldsteinJohn LoikeDavid SulzerLaura SantambrogioPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 2, p e28 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Zsolt Tallóczy Jose Martinez Danielle Joset Yonaton Ray Attila Gácser Sima Toussi Noboru Mizushima Joshua D Nosanchuk Harris Goldstein John Loike David Sulzer Laura Santambrogio Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
description	Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it is associated with a 2-fold higher risk for obtaining HIV and associated secondary infections. We report the first specific evidence that Meth at pharmacological concentrations exerts a direct immunosuppressive effect on dendritic cells and macrophages. As a weak base, Meth collapses the pH gradient across acidic organelles, including lysosomes and associated autophagic organelles. This in turn inhibits receptor-mediated phagocytosis of antibody-coated particles, MHC class II antigen processing by the endosomal-lysosomal pathway, and antigen presentation to splenic T cells by dendritic cells. More importantly Meth facilitates intracellular replication and inhibits intracellular killing of Candida albicans and Cryptococcus neoformans, two major AIDS-related pathogens. Meth exerts previously unreported direct immunosuppressive effects that contribute to increased risk of infection and exacerbate AIDS pathology.
format	article
author	Zsolt Tallóczy Jose Martinez Danielle Joset Yonaton Ray Attila Gácser Sima Toussi Noboru Mizushima Joshua D Nosanchuk Harris Goldstein John Loike David Sulzer Laura Santambrogio
author_facet	Zsolt Tallóczy Jose Martinez Danielle Joset Yonaton Ray Attila Gácser Sima Toussi Noboru Mizushima Joshua D Nosanchuk Harris Goldstein John Loike David Sulzer Laura Santambrogio
author_sort	Zsolt Tallóczy
title	Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
title_short	Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
title_full	Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
title_fullStr	Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
title_full_unstemmed	Methamphetamine inhibits antigen processing, presentation, and phagocytosis.
title_sort	methamphetamine inhibits antigen processing, presentation, and phagocytosis.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/a6eb9c55a95644e1bda78b25dd973a7b
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Methamphetamine inhibits antigen processing, presentation, and phagocytosis.

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