Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study

Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study

Gabriel Molina-Guzman,1 Thelma Beatriz González-Castro,2 Yazmín Hernández Díaz,2 Carlos Alfonso Tovilla-Zárate,3 Isela E Juárez-Rojop,3 Crystell Guadalupe Guzmán-Priego,3 Alma Genis,4 Sherezada Pool García,5 Mar&...

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Autores principales: Molina-Guzman G, González-Castro TB, Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop IE, Guzmán-Priego CG, Genis A, Pool García S, López-Narvaez ML, Rodriguez-Perez JM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
suicide
serotonin receptor
HTR2C gene
Mexican population
polymorphism.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/a6ecc9a5da0040e4835aea19af2107d8
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spelling oai:doaj.org-article:a6ecc9a5da0040e4835aea19af2107d82021-12-02T05:24:23ZGender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study1178-2021https://doaj.org/article/a6ecc9a5da0040e4835aea19af2107d82017-02-01T00:00:00Zhttps://www.dovepress.com/gender-differences-in-the-association-between-htr2c-gene-variants-and--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gabriel Molina-Guzman,1 Thelma Beatriz González-Castro,2 Yazmín Hernández Díaz,2 Carlos Alfonso Tovilla-Zárate,3 Isela E Juárez-Rojop,3 Crystell Guadalupe Guzmán-Priego,3 Alma Genis,4 Sherezada Pool García,5 María Lilia López-Narvaez,6 José Manuel Rodriguez-Perez7 1División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, 2División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, 3División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México; 4Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, Ciudad de México, México; 5Hospital General de Comalcalco, Secretaria de Salud, Comalcalco, Tabasco, México; 6Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México; 7Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México Background: The aim of this case–control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population. Subjects and methods: A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype. Results: In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09–0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24–10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts. Conclusion: These findings suggest a possible risk factor of the HTR2C gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association. Keywords: suicide, serotonin receptor, HTR2C gene, Mexican population, polymorphismMolina-Guzman GGonzález-Castro TBHernández-Díaz YTovilla-Zárate CAJuárez-Rojop IEGuzmán-Priego CGGenis APool García SLópez-Narvaez MLRodriguez-Perez JMDove Medical Pressarticlesuicideserotonin receptorHTR2C geneMexican populationpolymorphism.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 559-566 (2017)
institution DOAJ
collection DOAJ
language EN
topic suicide
serotonin receptor
HTR2C gene
Mexican population
polymorphism.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle suicide
serotonin receptor
HTR2C gene
Mexican population
polymorphism.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Molina-Guzman G
González-Castro TB
Hernández-Díaz Y
Tovilla-Zárate CA
Juárez-Rojop IE
Guzmán-Priego CG
Genis A
Pool García S
López-Narvaez ML
Rodriguez-Perez JM
Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
description Gabriel Molina-Guzman,1 Thelma Beatriz González-Castro,2 Yazmín Hernández Díaz,2 Carlos Alfonso Tovilla-Zárate,3 Isela E Juárez-Rojop,3 Crystell Guadalupe Guzmán-Priego,3 Alma Genis,4 Sherezada Pool García,5 María Lilia López-Narvaez,6 José Manuel Rodriguez-Perez7 1División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, 2División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, 3División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México; 4Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, Ciudad de México, México; 5Hospital General de Comalcalco, Secretaria de Salud, Comalcalco, Tabasco, México; 6Hospital General de Yajalón, Secretaría de Salud, Yajalón, Chiapas, México; 7Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México Background: The aim of this case–control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population. Subjects and methods: A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype. Results: In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09–0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24–10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts. Conclusion: These findings suggest a possible risk factor of the HTR2C gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association. Keywords: suicide, serotonin receptor, HTR2C gene, Mexican population, polymorphism
format article
author Molina-Guzman G
González-Castro TB
Hernández-Díaz Y
Tovilla-Zárate CA
Juárez-Rojop IE
Guzmán-Priego CG
Genis A
Pool García S
López-Narvaez ML
Rodriguez-Perez JM
author_facet Molina-Guzman G
González-Castro TB
Hernández-Díaz Y
Tovilla-Zárate CA
Juárez-Rojop IE
Guzmán-Priego CG
Genis A
Pool García S
López-Narvaez ML
Rodriguez-Perez JM
author_sort Molina-Guzman G
title Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
title_short Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
title_full Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
title_fullStr Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
title_full_unstemmed Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study
title_sort gender differences in the association between htr2c gene variants and suicidal behavior in a mexican population: a case–control study
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/a6ecc9a5da0040e4835aea19af2107d8
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