Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response

Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine wi...

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Autores principales:	Maria A. Rodriguez-Soto, Natalia Suarez Vargas, Alejandra Riveros, Carolina Muñoz Camargo, Juan C. Cruz, Nestor Sandoval, Juan C. Briceño
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tissue-engineered vascular grafts regeneration failure immune response Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a6f2baa5c8d4476b8bf03d4c41010af4
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spelling	oai:doaj.org-article:a6f2baa5c8d4476b8bf03d4c41010af42021-11-25T17:11:53ZFailure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response10.3390/cells101131402073-4409https://doaj.org/article/a6f2baa5c8d4476b8bf03d4c41010af42021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3140https://doaj.org/toc/2073-4409Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine with the tissue engineered vascular grafts (TEVGs), the cellular response is not yet close to mimicking the biological function of native vessels, and the understanding of the interactions between cells from the blood and the vascular wall with the material in operative conditions is much needed. These interactions change over time after the implantation of the graft. Here we aim to analyze the current knowledge in bio-molecular interactions between blood components, cells and materials that lead either to an early failure or to the stabilization of the vascular graft before the wall regeneration begins.Maria A. Rodriguez-SotoNatalia Suarez VargasAlejandra RiverosCarolina Muñoz CamargoJuan C. CruzNestor SandovalJuan C. BriceñoMDPI AGarticletissue-engineered vascular graftsregenerationfailureimmune responseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3140, p 3140 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue-engineered vascular grafts regeneration failure immune response Biology (General) QH301-705.5
spellingShingle	tissue-engineered vascular grafts regeneration failure immune response Biology (General) QH301-705.5 Maria A. Rodriguez-Soto Natalia Suarez Vargas Alejandra Riveros Carolina Muñoz Camargo Juan C. Cruz Nestor Sandoval Juan C. Briceño Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
description	Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine with the tissue engineered vascular grafts (TEVGs), the cellular response is not yet close to mimicking the biological function of native vessels, and the understanding of the interactions between cells from the blood and the vascular wall with the material in operative conditions is much needed. These interactions change over time after the implantation of the graft. Here we aim to analyze the current knowledge in bio-molecular interactions between blood components, cells and materials that lead either to an early failure or to the stabilization of the vascular graft before the wall regeneration begins.
format	article
author	Maria A. Rodriguez-Soto Natalia Suarez Vargas Alejandra Riveros Carolina Muñoz Camargo Juan C. Cruz Nestor Sandoval Juan C. Briceño
author_facet	Maria A. Rodriguez-Soto Natalia Suarez Vargas Alejandra Riveros Carolina Muñoz Camargo Juan C. Cruz Nestor Sandoval Juan C. Briceño
author_sort	Maria A. Rodriguez-Soto
title	Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
title_short	Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
title_full	Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
title_fullStr	Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
title_full_unstemmed	Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
title_sort	failure analysis of tevg’s i: overcoming the initial stages of blood material interaction and stabilization of the immune response
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a6f2baa5c8d4476b8bf03d4c41010af4
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Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response

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