Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.
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Nature Portfolio
2019
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oai:doaj.org-article:a6f687718ebe47d89abfb1ed664dd4fb2021-12-02T16:57:45ZMultiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ10.1038/s41467-019-09216-82041-1723https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09216-8https://doaj.org/toc/2041-1723How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.Thomas P. JensenKaiyu ZhengNicholas ColeJonathan S. MarvinLoren L. LoogerDmitri A. RusakovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
description |
How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons. |
format |
article |
author |
Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov |
author_facet |
Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov |
author_sort |
Thomas P. Jensen |
title |
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
title_short |
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
title_full |
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
title_fullStr |
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
title_full_unstemmed |
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ |
title_sort |
multiplex imaging relates quantal glutamate release to presynaptic ca2+ homeostasis at multiple synapses in situ |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb |
work_keys_str_mv |
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1718382463390056448 |