Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ

How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.

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Autores principales: Thomas P. Jensen, Kaiyu Zheng, Nicholas Cole, Jonathan S. Marvin, Loren L. Looger, Dmitri A. Rusakov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb
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spelling oai:doaj.org-article:a6f687718ebe47d89abfb1ed664dd4fb2021-12-02T16:57:45ZMultiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ10.1038/s41467-019-09216-82041-1723https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09216-8https://doaj.org/toc/2041-1723How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.Thomas P. JensenKaiyu ZhengNicholas ColeJonathan S. MarvinLoren L. LoogerDmitri A. RusakovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thomas P. Jensen
Kaiyu Zheng
Nicholas Cole
Jonathan S. Marvin
Loren L. Looger
Dmitri A. Rusakov
Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
description How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.
format article
author Thomas P. Jensen
Kaiyu Zheng
Nicholas Cole
Jonathan S. Marvin
Loren L. Looger
Dmitri A. Rusakov
author_facet Thomas P. Jensen
Kaiyu Zheng
Nicholas Cole
Jonathan S. Marvin
Loren L. Looger
Dmitri A. Rusakov
author_sort Thomas P. Jensen
title Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_short Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_full Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_fullStr Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_full_unstemmed Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_sort multiplex imaging relates quantal glutamate release to presynaptic ca2+ homeostasis at multiple synapses in situ
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb
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AT kaiyuzheng multipleximagingrelatesquantalglutamatereleasetopresynapticca2homeostasisatmultiplesynapsesinsitu
AT nicholascole multipleximagingrelatesquantalglutamatereleasetopresynapticca2homeostasisatmultiplesynapsesinsitu
AT jonathansmarvin multipleximagingrelatesquantalglutamatereleasetopresynapticca2homeostasisatmultiplesynapsesinsitu
AT lorenllooger multipleximagingrelatesquantalglutamatereleasetopresynapticca2homeostasisatmultiplesynapsesinsitu
AT dmitriarusakov multipleximagingrelatesquantalglutamatereleasetopresynapticca2homeostasisatmultiplesynapsesinsitu
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