Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ

How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.

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Bibliographic Details
Main Authors:	Thomas P. Jensen, Kaiyu Zheng, Nicholas Cole, Jonathan S. Marvin, Loren L. Looger, Dmitri A. Rusakov
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb
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spelling	oai:doaj.org-article:a6f687718ebe47d89abfb1ed664dd4fb2021-12-02T16:57:45ZMultiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ10.1038/s41467-019-09216-82041-1723https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09216-8https://doaj.org/toc/2041-1723How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.Thomas P. JensenKaiyu ZhengNicholas ColeJonathan S. MarvinLoren L. LoogerDmitri A. RusakovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
description	How neurotransmitter release relates to presynaptic calcium dynamics is not fully understood. Here the authors develop an approach based on FLIM and optical quantal analysis for simultaneous imaging of calcium dynamics and glutamate release at presynaptic boutons.
format	article
author	Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov
author_facet	Thomas P. Jensen Kaiyu Zheng Nicholas Cole Jonathan S. Marvin Loren L. Looger Dmitri A. Rusakov
author_sort	Thomas P. Jensen
title	Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_short	Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_full	Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_fullStr	Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_full_unstemmed	Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
title_sort	multiplex imaging relates quantal glutamate release to presynaptic ca2+ homeostasis at multiple synapses in situ
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a6f687718ebe47d89abfb1ed664dd4fb
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Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ

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