Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune response through cGAS and STING resulting in cognitiv...

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Autores principales:	Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6f77446056c4920834d3c51e49c5a27
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spelling	oai:doaj.org-article:a6f77446056c4920834d3c51e49c5a272021-11-21T12:36:27ZTau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation10.1038/s41467-021-26851-22041-1723https://doaj.org/article/a6f77446056c4920834d3c51e49c5a272021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26851-2https://doaj.org/toc/2041-1723Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune response through cGAS and STING resulting in cognitive impairment.Meihua JinHiroki ShiwakuHikari TanakaTakayuki ObitaSakurako OhuchiYuki YoshiokaXiaocen JinKanoh KondoKyota FujitaHidenori HommaKazuyuki NakajimaMineyuki MizuguchiHitoshi OkazawaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meihua Jin Hiroki Shiwaku Hikari Tanaka Takayuki Obita Sakurako Ohuchi Yuki Yoshioka Xiaocen Jin Kanoh Kondo Kyota Fujita Hidenori Homma Kazuyuki Nakajima Mineyuki Mizuguchi Hitoshi Okazawa Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
description	Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune response through cGAS and STING resulting in cognitive impairment.
format	article
author	Meihua Jin Hiroki Shiwaku Hikari Tanaka Takayuki Obita Sakurako Ohuchi Yuki Yoshioka Xiaocen Jin Kanoh Kondo Kyota Fujita Hidenori Homma Kazuyuki Nakajima Mineyuki Mizuguchi Hitoshi Okazawa
author_facet	Meihua Jin Hiroki Shiwaku Hikari Tanaka Takayuki Obita Sakurako Ohuchi Yuki Yoshioka Xiaocen Jin Kanoh Kondo Kyota Fujita Hidenori Homma Kazuyuki Nakajima Mineyuki Mizuguchi Hitoshi Okazawa
author_sort	Meihua Jin
title	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
title_short	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
title_full	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
title_fullStr	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
title_full_unstemmed	Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
title_sort	tau activates microglia via the pqbp1-cgas-sting pathway to promote brain inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6f77446056c4920834d3c51e49c5a27
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Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

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