Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis

Abstract Cold atmospheric plasma generates free radicals through the ionization of air at room temperature. Its effect and safety profile as a treatment modality for atopic dermatitis lesions have not been evaluated prospectively enough. We aimed to investigate the effect and safety of cold atmosphe...

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Autores principales:	Young Jae Kim, Dong Jun Lim, Mi Young Lee, Woo Jin Lee, Sung Eun Chang, Chong Hyun Won
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6f7a94c03d34c4c948e57d2c011887f
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spelling	oai:doaj.org-article:a6f7a94c03d34c4c948e57d2c011887f2021-12-02T15:33:12ZProspective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis10.1038/s41598-021-93941-y2045-2322https://doaj.org/article/a6f7a94c03d34c4c948e57d2c011887f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93941-yhttps://doaj.org/toc/2045-2322Abstract Cold atmospheric plasma generates free radicals through the ionization of air at room temperature. Its effect and safety profile as a treatment modality for atopic dermatitis lesions have not been evaluated prospectively enough. We aimed to investigate the effect and safety of cold atmospheric plasma in patients with atopic dermatitis with a prospective pilot study. Cold atmospheric plasma treatment or sham control treatment were applied respectively in randomly assigned and symmetric skin lesions. Three treatment sessions were performed at weeks 0, 1, and 2. Clinical severity indices were assessed at weeks 0, 1, 2, and 4 after treatment. Additionally, the microbial characteristics of the lesions before and after treatments were analyzed. We included 22 patients with mild to moderate atopic dermatitis presented with symmetric lesions. We found that cold atmospheric plasma can alleviate the clinical severity of atopic dermatitis. Modified atopic dermatitis antecubital severity and eczema area and severity index score were significantly decreased in the treated group. Furthermore, scoring of atopic dermatitis score and pruritic visual analog scales significantly improved. Microbiome analysis revealed significantly reduced proportion of Staphylococcus aureus in the treated group. Cold atmospheric plasma can significantly improve mild and moderate atopic dermatitis without safety issues.Young Jae KimDong Jun LimMi Young LeeWoo Jin LeeSung Eun ChangChong Hyun WonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Jae Kim Dong Jun Lim Mi Young Lee Woo Jin Lee Sung Eun Chang Chong Hyun Won Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
description	Abstract Cold atmospheric plasma generates free radicals through the ionization of air at room temperature. Its effect and safety profile as a treatment modality for atopic dermatitis lesions have not been evaluated prospectively enough. We aimed to investigate the effect and safety of cold atmospheric plasma in patients with atopic dermatitis with a prospective pilot study. Cold atmospheric plasma treatment or sham control treatment were applied respectively in randomly assigned and symmetric skin lesions. Three treatment sessions were performed at weeks 0, 1, and 2. Clinical severity indices were assessed at weeks 0, 1, 2, and 4 after treatment. Additionally, the microbial characteristics of the lesions before and after treatments were analyzed. We included 22 patients with mild to moderate atopic dermatitis presented with symmetric lesions. We found that cold atmospheric plasma can alleviate the clinical severity of atopic dermatitis. Modified atopic dermatitis antecubital severity and eczema area and severity index score were significantly decreased in the treated group. Furthermore, scoring of atopic dermatitis score and pruritic visual analog scales significantly improved. Microbiome analysis revealed significantly reduced proportion of Staphylococcus aureus in the treated group. Cold atmospheric plasma can significantly improve mild and moderate atopic dermatitis without safety issues.
format	article
author	Young Jae Kim Dong Jun Lim Mi Young Lee Woo Jin Lee Sung Eun Chang Chong Hyun Won
author_facet	Young Jae Kim Dong Jun Lim Mi Young Lee Woo Jin Lee Sung Eun Chang Chong Hyun Won
author_sort	Young Jae Kim
title	Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
title_short	Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
title_full	Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
title_fullStr	Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
title_full_unstemmed	Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
title_sort	prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6f7a94c03d34c4c948e57d2c011887f
work_keys_str_mv	AT youngjaekim prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis AT dongjunlim prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis AT miyounglee prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis AT woojinlee prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis AT sungeunchang prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis AT chonghyunwon prospectivecomparativeclinicalpilotstudyofcoldatmosphericplasmadeviceinthetreatmentofatopicdermatitis
_version_	1718387099622703104

Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis

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