The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutroph...

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Autores principales:	Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6f8dbdcb34b42c0a82ada447cf8eac9
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spelling	oai:doaj.org-article:a6f8dbdcb34b42c0a82ada447cf8eac92021-12-02T14:41:13ZThe platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure10.1038/s41467-020-15584-32041-1723https://doaj.org/article/a6f8dbdcb34b42c0a82ada447cf8eac92020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15584-3https://doaj.org/toc/2041-1723The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutrophil driven inflammation.Abhishek ChauhanLozan SheriffMohammed T. HussainGwilym J. WebbDaniel A. PattenEmma L. ShepherdRobert ShawChristopher J. WestonDebashis HaldarSamuel BourkeRajan BhandariStephanie WatsonDavid H. AdamsSteve P. WatsonPatricia F. LalorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
description	The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutrophil driven inflammation.
format	article
author	Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor
author_facet	Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor
author_sort	Abhishek Chauhan
title	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_short	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_full	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_fullStr	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_full_unstemmed	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_sort	platelet receptor clec-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a6f8dbdcb34b42c0a82ada447cf8eac9
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The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

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