PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.

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Autores principales:	Corina T. Madreiter-Sokolowski, Christiane Klec, Warisara Parichatikanond, Sarah Stryeck, Benjamin Gottschalk, Sergio Pulido, Rene Rost, Emrah Eroglu, Nicole A. Hofmann, Alexander I. Bondarenko, Tobias Madl, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F. Graier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6f961a846b34d569bfe653019af44f9
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spelling	oai:doaj.org-article:a6f961a846b34d569bfe653019af44f92021-12-02T15:35:18ZPRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells10.1038/ncomms128972041-1723https://doaj.org/article/a6f961a846b34d569bfe653019af44f92016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12897https://doaj.org/toc/2041-1723MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.Corina T. Madreiter-SokolowskiChristiane KlecWarisara ParichatikanondSarah StryeckBenjamin GottschalkSergio PulidoRene RostEmrah ErogluNicole A. HofmannAlexander I. BondarenkoTobias MadlMarkus Waldeck-WeiermairRoland MalliWolfgang F. GraierNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Corina T. Madreiter-Sokolowski Christiane Klec Warisara Parichatikanond Sarah Stryeck Benjamin Gottschalk Sergio Pulido Rene Rost Emrah Eroglu Nicole A. Hofmann Alexander I. Bondarenko Tobias Madl Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
description	MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.
format	article
author	Corina T. Madreiter-Sokolowski Christiane Klec Warisara Parichatikanond Sarah Stryeck Benjamin Gottschalk Sergio Pulido Rene Rost Emrah Eroglu Nicole A. Hofmann Alexander I. Bondarenko Tobias Madl Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier
author_facet	Corina T. Madreiter-Sokolowski Christiane Klec Warisara Parichatikanond Sarah Stryeck Benjamin Gottschalk Sergio Pulido Rene Rost Emrah Eroglu Nicole A. Hofmann Alexander I. Bondarenko Tobias Madl Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier
author_sort	Corina T. Madreiter-Sokolowski
title	PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
title_short	PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
title_full	PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
title_fullStr	PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
title_full_unstemmed	PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
title_sort	prmt1-mediated methylation of micu1 determines the ucp2/3 dependency of mitochondrial ca2+ uptake in immortalized cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a6f961a846b34d569bfe653019af44f9
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PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

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