Multi-level inhibition of coronavirus replication by chemical ER stress

Multi-level inhibition of coronavirus replication by chemical ER stress

Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inh...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M. Lienhard Schmitz, John Ziebuhr, Michael Kracht
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inhibiting coronavirus replication at multiple levels.

Ejemplares similares