Multi-level inhibition of coronavirus replication by chemical ER stress

Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inh...

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Autores principales:	Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M. Lienhard Schmitz, John Ziebuhr, Michael Kracht
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912
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spelling	oai:doaj.org-article:a6f9af13b42d437eab2e9eaf4c3fe9122021-12-02T17:26:56ZMulti-level inhibition of coronavirus replication by chemical ER stress10.1038/s41467-021-25551-12041-1723https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe9122021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25551-1https://doaj.org/toc/2041-1723Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inhibiting coronavirus replication at multiple levels.Mohammed Samer ShabanChristin MüllerChristin Mayr-BuroHendrik WeiserJohanna Meier-SoelchBenadict Vincent AlbertAxel WeberUwe LinneTorsten HainIlya BabayevNadja KarlNina HofmannStephan BeckerSusanne HeroldM. Lienhard SchmitzJohn ZiebuhrMichael KrachtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohammed Samer Shaban Christin Müller Christin Mayr-Buro Hendrik Weiser Johanna Meier-Soelch Benadict Vincent Albert Axel Weber Uwe Linne Torsten Hain Ilya Babayev Nadja Karl Nina Hofmann Stephan Becker Susanne Herold M. Lienhard Schmitz John Ziebuhr Michael Kracht Multi-level inhibition of coronavirus replication by chemical ER stress
description	Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inhibiting coronavirus replication at multiple levels.
format	article
author	Mohammed Samer Shaban Christin Müller Christin Mayr-Buro Hendrik Weiser Johanna Meier-Soelch Benadict Vincent Albert Axel Weber Uwe Linne Torsten Hain Ilya Babayev Nadja Karl Nina Hofmann Stephan Becker Susanne Herold M. Lienhard Schmitz John Ziebuhr Michael Kracht
author_facet	Mohammed Samer Shaban Christin Müller Christin Mayr-Buro Hendrik Weiser Johanna Meier-Soelch Benadict Vincent Albert Axel Weber Uwe Linne Torsten Hain Ilya Babayev Nadja Karl Nina Hofmann Stephan Becker Susanne Herold M. Lienhard Schmitz John Ziebuhr Michael Kracht
author_sort	Mohammed Samer Shaban
title	Multi-level inhibition of coronavirus replication by chemical ER stress
title_short	Multi-level inhibition of coronavirus replication by chemical ER stress
title_full	Multi-level inhibition of coronavirus replication by chemical ER stress
title_fullStr	Multi-level inhibition of coronavirus replication by chemical ER stress
title_full_unstemmed	Multi-level inhibition of coronavirus replication by chemical ER stress
title_sort	multi-level inhibition of coronavirus replication by chemical er stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912
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Multi-level inhibition of coronavirus replication by chemical ER stress

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