Multi-level inhibition of coronavirus replication by chemical ER stress

Multi-level inhibition of coronavirus replication by chemical ER stress

Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inh...

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Main Authors: Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M. Lienhard Schmitz, John Ziebuhr, Michael Kracht
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912
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https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912

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