Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.

<h4>Objective</h4>Evidence for an association between uterine leiomyoma and increased risk of endometriosis is limited by small sample sizes and short follow-up periods. We assessed this association in a large nationwide sample with 14 years of data.<h4>Design</h4>Data were s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kent Yu-Hsien Lin, Chih-Yi Yang, Alan Lam, Cherry Yin-Yi Chang, Wu-Chou Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6f9f373dc7d43a5ac622b13f86f2a2d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6f9f373dc7d43a5ac622b13f86f2a2d
record_format	dspace
spelling	oai:doaj.org-article:a6f9f373dc7d43a5ac622b13f86f2a2d2021-12-02T20:19:27ZUterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.1932-620310.1371/journal.pone.0256772https://doaj.org/article/a6f9f373dc7d43a5ac622b13f86f2a2d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256772https://doaj.org/toc/1932-6203<h4>Objective</h4>Evidence for an association between uterine leiomyoma and increased risk of endometriosis is limited by small sample sizes and short follow-up periods. We assessed this association in a large nationwide sample with 14 years of data.<h4>Design</h4>Data were sourced from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000).<h4>Materials and methods</h4>We identified 31,239 women aged ≥20 years diagnosed with uterine leiomyoma (International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] code 218) between Jan 1, 2000 and Dec 31, 2012, who were matched with 124,956 controls (1:4) by 5-year age groups and year of diagnosis. Follow-up was from the date of LHID2000 entry to the first occurrence of endometriosis, loss to follow-up, insurance termination, or until December 31, 2013, whichever was earlier.<h4>Results</h4>In Cox regression analysis, the adjusted hazard ratio (aHR) for endometriosis in women with uterine leiomyoma was 6.44 (95% CI, 6.18, 6.72) compared with controls. The risk of endometriosis was significantly increased in women with uterine leiomyoma and comorbidities of tube-ovarian infection (aHR 2.86; 95% CI, 1.28, 6.36), endometritis (1.14; 1.06, 1.24), infertility (1.26; 1.16, 1.37), or allergic diseases (1.11; 1.05, 1.17). Having both uterine leiomyoma and endometritis significantly increased the risk of endometriosis (aHR 6.73; 95% CI, 6.07, 7.45) versus having only uterine leiomyoma (6.61; 6.33, 6.91) or endometritis (1.49; 1.31, 1.69). Similarly, having both uterine leiomyoma and infertility significantly increased the risk of endometriosis (aHR 6.95; 95% CI, 6.21, 7.78) versus having only uterine leiomyoma (6.66; 6.38, 6.96) or infertility (1.78; 1.57, 2.02).<h4>Conclusions</h4>A diagnosis of uterine leiomyoma appears to increase the risk of endometriosis. Patients presenting with uterine fibroids should be encouraged to give informed consent for possible simultaneous surgical treatment of endometriosis.Kent Yu-Hsien LinChih-Yi YangAlan LamCherry Yin-Yi ChangWu-Chou LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256772 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kent Yu-Hsien Lin Chih-Yi Yang Alan Lam Cherry Yin-Yi Chang Wu-Chou Lin Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
description	<h4>Objective</h4>Evidence for an association between uterine leiomyoma and increased risk of endometriosis is limited by small sample sizes and short follow-up periods. We assessed this association in a large nationwide sample with 14 years of data.<h4>Design</h4>Data were sourced from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000).<h4>Materials and methods</h4>We identified 31,239 women aged ≥20 years diagnosed with uterine leiomyoma (International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] code 218) between Jan 1, 2000 and Dec 31, 2012, who were matched with 124,956 controls (1:4) by 5-year age groups and year of diagnosis. Follow-up was from the date of LHID2000 entry to the first occurrence of endometriosis, loss to follow-up, insurance termination, or until December 31, 2013, whichever was earlier.<h4>Results</h4>In Cox regression analysis, the adjusted hazard ratio (aHR) for endometriosis in women with uterine leiomyoma was 6.44 (95% CI, 6.18, 6.72) compared with controls. The risk of endometriosis was significantly increased in women with uterine leiomyoma and comorbidities of tube-ovarian infection (aHR 2.86; 95% CI, 1.28, 6.36), endometritis (1.14; 1.06, 1.24), infertility (1.26; 1.16, 1.37), or allergic diseases (1.11; 1.05, 1.17). Having both uterine leiomyoma and endometritis significantly increased the risk of endometriosis (aHR 6.73; 95% CI, 6.07, 7.45) versus having only uterine leiomyoma (6.61; 6.33, 6.91) or endometritis (1.49; 1.31, 1.69). Similarly, having both uterine leiomyoma and infertility significantly increased the risk of endometriosis (aHR 6.95; 95% CI, 6.21, 7.78) versus having only uterine leiomyoma (6.66; 6.38, 6.96) or infertility (1.78; 1.57, 2.02).<h4>Conclusions</h4>A diagnosis of uterine leiomyoma appears to increase the risk of endometriosis. Patients presenting with uterine fibroids should be encouraged to give informed consent for possible simultaneous surgical treatment of endometriosis.
format	article
author	Kent Yu-Hsien Lin Chih-Yi Yang Alan Lam Cherry Yin-Yi Chang Wu-Chou Lin
author_facet	Kent Yu-Hsien Lin Chih-Yi Yang Alan Lam Cherry Yin-Yi Chang Wu-Chou Lin
author_sort	Kent Yu-Hsien Lin
title	Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
title_short	Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
title_full	Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
title_fullStr	Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
title_full_unstemmed	Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.
title_sort	uterine leiomyoma is associated with the risk of developing endometriosis: a nationwide cohort study involving 156,195 women.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a6f9f373dc7d43a5ac622b13f86f2a2d
work_keys_str_mv	AT kentyuhsienlin uterineleiomyomaisassociatedwiththeriskofdevelopingendometriosisanationwidecohortstudyinvolving156195women AT chihyiyang uterineleiomyomaisassociatedwiththeriskofdevelopingendometriosisanationwidecohortstudyinvolving156195women AT alanlam uterineleiomyomaisassociatedwiththeriskofdevelopingendometriosisanationwidecohortstudyinvolving156195women AT cherryyinyichang uterineleiomyomaisassociatedwiththeriskofdevelopingendometriosisanationwidecohortstudyinvolving156195women AT wuchoulin uterineleiomyomaisassociatedwiththeriskofdevelopingendometriosisanationwidecohortstudyinvolving156195women
_version_	1718374182511706112

Uterine leiomyoma is associated with the risk of developing endometriosis: A nationwide cohort study involving 156,195 women.

Ejemplares similares