Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands
Bart Hoogveldt1, Benoît Rive2, Johan Severens3, Khaled Maman4, Chantal Guilhaume51Field Product Management, Lundbeck BV, Amsterdam, The Netherlands; 2Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France; 3Institute of Health Policy and Management, Erasmus University Rott...
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Dove Medical Press
2011
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oai:doaj.org-article:a6fa6c52e8cd4672a1cdb96a20e5ca862021-12-02T02:36:10ZCost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands1176-63281178-2021https://doaj.org/article/a6fa6c52e8cd4672a1cdb96a20e5ca862011-06-01T00:00:00Zhttp://www.dovepress.com/cost-effectiveness-analysis-of-memantine-for-moderate-to-severe-alzhei-a7658https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Bart Hoogveldt1, Benoît Rive2, Johan Severens3, Khaled Maman4, Chantal Guilhaume51Field Product Management, Lundbeck BV, Amsterdam, The Netherlands; 2Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France; 3Institute of Health Policy and Management, Erasmus University Rotterdam, The Netherlands; 4Creativ Research SAS, Paris, France; 5Global Evidence and Value Development, Sanofi-Aventis, Paris, FranceObjective: The purpose of this study was to estimate the cost-effectiveness of memantine relative to standard care in patients with moderate-to-severe Alzheimer's disease in the Netherlands.Methods: A country-adapted five-year Markov model simulated disease progression through a series of states, defined by dependency and disease severity. Transition probabilities were derived from trials, with utility and epidemiological data obtained from a longitudinal Dutch cohort. Cost-effectiveness was described in terms of quality-adjusted life years and time spent in a nondependent state or in a moderate severity state.Results: Memantine monotherapy versus standard care led to 0.058 quality-adjusted life years gained (1.207 versus 1.265), longer time in a nondependent state (from 1.602 to 1.751 years) and in a moderate state (from 2.051 to 2.141 years), and no additional costs (€113,927 versus €110,097). Robustness of results was confirmed through sensitivity analyses.Conclusion: Memantine is dominant compared with standard care in the Netherlands. Results are consistent with similar economic evaluations in other countries.Keywords: memantine, Alzheimer's disease, cost-effectiveness analysis, Netherlands, cholinesterase inhibitorsHoogveldt BRive B, Severens JMaman KGuilhaume CDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 313-317 (2011) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hoogveldt B Rive B, Severens J Maman K Guilhaume C Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| description |
Bart Hoogveldt1, Benoît Rive2, Johan Severens3, Khaled Maman4, Chantal Guilhaume51Field Product Management, Lundbeck BV, Amsterdam, The Netherlands; 2Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France; 3Institute of Health Policy and Management, Erasmus University Rotterdam, The Netherlands; 4Creativ Research SAS, Paris, France; 5Global Evidence and Value Development, Sanofi-Aventis, Paris, FranceObjective: The purpose of this study was to estimate the cost-effectiveness of memantine relative to standard care in patients with moderate-to-severe Alzheimer's disease in the Netherlands.Methods: A country-adapted five-year Markov model simulated disease progression through a series of states, defined by dependency and disease severity. Transition probabilities were derived from trials, with utility and epidemiological data obtained from a longitudinal Dutch cohort. Cost-effectiveness was described in terms of quality-adjusted life years and time spent in a nondependent state or in a moderate severity state.Results: Memantine monotherapy versus standard care led to 0.058 quality-adjusted life years gained (1.207 versus 1.265), longer time in a nondependent state (from 1.602 to 1.751 years) and in a moderate state (from 2.051 to 2.141 years), and no additional costs (€113,927 versus €110,097). Robustness of results was confirmed through sensitivity analyses.Conclusion: Memantine is dominant compared with standard care in the Netherlands. Results are consistent with similar economic evaluations in other countries.Keywords: memantine, Alzheimer's disease, cost-effectiveness analysis, Netherlands, cholinesterase inhibitors |
| format |
article |
| author |
Hoogveldt B Rive B, Severens J Maman K Guilhaume C |
| author_facet |
Hoogveldt B Rive B, Severens J Maman K Guilhaume C |
| author_sort |
Hoogveldt B |
| title |
Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| title_short |
Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| title_full |
Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| title_fullStr |
Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| title_full_unstemmed |
Cost-effectiveness analysis of memantine for moderate-to-severe Alzheimer's disease in the Netherlands |
| title_sort |
cost-effectiveness analysis of memantine for moderate-to-severe alzheimer's disease in the netherlands |
| publisher |
Dove Medical Press |
| publishDate |
2011 |
| url |
https://doaj.org/article/a6fa6c52e8cd4672a1cdb96a20e5ca86 |
| work_keys_str_mv |
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