Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals

Abstract Functional neuroimaging studies in obesity have identified alterations in the connectivity within the reward network leading to decreased homeostatic control of ingestive behavior. However, the neural mechanisms underlying sex differences in the prevalence of food addiction in obesity is un...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Soumya Ravichandran, Ravi R. Bhatt, Bilal Pandit, Vadim Osadchiy, Anita Alaverdyan, Priten Vora, Jean Stains, Bruce Naliboff, Emeran A. Mayer, Arpana Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6fb392db49a44ab9c6c395f27867773
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6fb392db49a44ab9c6c395f27867773
record_format	dspace
spelling	oai:doaj.org-article:a6fb392db49a44ab9c6c395f278677732021-12-02T14:27:02ZAlterations in reward network functional connectivity are associated with increased food addiction in obese individuals10.1038/s41598-021-83116-02045-2322https://doaj.org/article/a6fb392db49a44ab9c6c395f278677732021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83116-0https://doaj.org/toc/2045-2322Abstract Functional neuroimaging studies in obesity have identified alterations in the connectivity within the reward network leading to decreased homeostatic control of ingestive behavior. However, the neural mechanisms underlying sex differences in the prevalence of food addiction in obesity is unknown. The aim of the study was to identify functional connectivity alterations associated with: (1) Food addiction, (2) Sex- differences in food addiction, (3) Ingestive behaviors. 150 participants (females: N = 103, males: N = 47; food addiction: N = 40, no food addiction: N = 110) with high BMI ≥ 25 kg/m2 underwent functional resting state MRIs. Participants were administered the Yale Food Addiction Scale (YFAS), to determine diagnostic criteria for food addiction (YFAS Symptom Count ≥ 3 with clinically significant impairment or distress), and completed ingestive behavior questionnaires. Connectivity differences were analyzed using a general linear model in the CONN Toolbox and images were segmented using the Schaefer 400, Harvard–Oxford Subcortical, and Ascending Arousal Network atlases. Significant connectivities and clinical variables were correlated. Statistical significance was corrected for multiple comparisons at q < .05. (1) Individuals with food addiction had greater connectivity between brainstem regions and the orbital frontal gyrus compared to individuals with no food addiction. (2) Females with food addiction had greater connectivity in the salience and emotional regulation networks and lowered connectivity between the default mode network and central executive network compared to males with food addiction. (3) Increased connectivity between regions of the reward network was positively associated with scores on the General Food Cravings Questionnaire-Trait, indicative of greater food cravings in individuals with food addiction. Individuals with food addiction showed greater connectivity between regions of the reward network suggesting dysregulation of the dopaminergic pathway. Additionally, greater connectivity in the locus coeruleus could indicate that the maladaptive food behaviors displayed by individuals with food addiction serve as a coping mechanism in response to pathological anxiety and stress. Sex differences in functional connectivity suggest that females with food addiction engage more in emotional overeating and less cognitive control and homeostatic processing compared to males. These mechanistic pathways may have clinical implications for understanding the sex-dependent variability in response to diet interventions.Soumya RavichandranRavi R. BhattBilal PanditVadim OsadchiyAnita AlaverdyanPriten VoraJean StainsBruce NaliboffEmeran A. MayerArpana GuptaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soumya Ravichandran Ravi R. Bhatt Bilal Pandit Vadim Osadchiy Anita Alaverdyan Priten Vora Jean Stains Bruce Naliboff Emeran A. Mayer Arpana Gupta Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
description	Abstract Functional neuroimaging studies in obesity have identified alterations in the connectivity within the reward network leading to decreased homeostatic control of ingestive behavior. However, the neural mechanisms underlying sex differences in the prevalence of food addiction in obesity is unknown. The aim of the study was to identify functional connectivity alterations associated with: (1) Food addiction, (2) Sex- differences in food addiction, (3) Ingestive behaviors. 150 participants (females: N = 103, males: N = 47; food addiction: N = 40, no food addiction: N = 110) with high BMI ≥ 25 kg/m2 underwent functional resting state MRIs. Participants were administered the Yale Food Addiction Scale (YFAS), to determine diagnostic criteria for food addiction (YFAS Symptom Count ≥ 3 with clinically significant impairment or distress), and completed ingestive behavior questionnaires. Connectivity differences were analyzed using a general linear model in the CONN Toolbox and images were segmented using the Schaefer 400, Harvard–Oxford Subcortical, and Ascending Arousal Network atlases. Significant connectivities and clinical variables were correlated. Statistical significance was corrected for multiple comparisons at q < .05. (1) Individuals with food addiction had greater connectivity between brainstem regions and the orbital frontal gyrus compared to individuals with no food addiction. (2) Females with food addiction had greater connectivity in the salience and emotional regulation networks and lowered connectivity between the default mode network and central executive network compared to males with food addiction. (3) Increased connectivity between regions of the reward network was positively associated with scores on the General Food Cravings Questionnaire-Trait, indicative of greater food cravings in individuals with food addiction. Individuals with food addiction showed greater connectivity between regions of the reward network suggesting dysregulation of the dopaminergic pathway. Additionally, greater connectivity in the locus coeruleus could indicate that the maladaptive food behaviors displayed by individuals with food addiction serve as a coping mechanism in response to pathological anxiety and stress. Sex differences in functional connectivity suggest that females with food addiction engage more in emotional overeating and less cognitive control and homeostatic processing compared to males. These mechanistic pathways may have clinical implications for understanding the sex-dependent variability in response to diet interventions.
format	article
author	Soumya Ravichandran Ravi R. Bhatt Bilal Pandit Vadim Osadchiy Anita Alaverdyan Priten Vora Jean Stains Bruce Naliboff Emeran A. Mayer Arpana Gupta
author_facet	Soumya Ravichandran Ravi R. Bhatt Bilal Pandit Vadim Osadchiy Anita Alaverdyan Priten Vora Jean Stains Bruce Naliboff Emeran A. Mayer Arpana Gupta
author_sort	Soumya Ravichandran
title	Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
title_short	Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
title_full	Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
title_fullStr	Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
title_full_unstemmed	Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
title_sort	alterations in reward network functional connectivity are associated with increased food addiction in obese individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6fb392db49a44ab9c6c395f27867773
work_keys_str_mv	AT soumyaravichandran alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT ravirbhatt alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT bilalpandit alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT vadimosadchiy alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT anitaalaverdyan alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT pritenvora alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT jeanstains alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT brucenaliboff alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT emeranamayer alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals AT arpanagupta alterationsinrewardnetworkfunctionalconnectivityareassociatedwithincreasedfoodaddictioninobeseindividuals
_version_	1718391329972551680

Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals

Ejemplares similares