Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas

Abstract The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing...

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Autores principales:	Sagarika Banerjee, Tian Tian, Zhi Wei, Kristen N. Peck, Natalie Shih, Ara A. Chalian, Bert W. O’Malley, Gregory S. Weinstein, Michael D. Feldman, James Alwine, Erle S. Robertson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6fcde7e76e04af0b25047f7738c8835
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spelling	oai:doaj.org-article:a6fcde7e76e04af0b25047f7738c88352021-12-02T16:07:46ZMicrobial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas10.1038/s41598-017-03466-62045-2322https://doaj.org/article/a6fcde7e76e04af0b25047f7738c88352017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03466-6https://doaj.org/toc/2045-2322Abstract The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing to establish microbial signatures unique to human oral and oropharyngeal squamous cell carcinomas (OCSCC/OPSCC). Signatures for DNA and RNA viruses including oncogenic viruses, gram positive and negative bacteria, fungi and parasites were detected. Cluster and topological analyses identified 2 distinct groups of microbial signatures related to OCSCCs/OPSCCs. Results were validated by probe capture next generation sequencing; the data from which also provided a comprehensive map of integration sites and chromosomal hotspots for micro-organism genomic insertions. Identification of these microbial signatures and their integration sites may provide biomarkers for OCSCC/OPSCC diagnosis and prognosis as well as novel avenues for study of their potential role in OCSCCs/OPSCCs.Sagarika BanerjeeTian TianZhi WeiKristen N. PeckNatalie ShihAra A. ChalianBert W. O’MalleyGregory S. WeinsteinMichael D. FeldmanJames AlwineErle S. RobertsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-20 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sagarika Banerjee Tian Tian Zhi Wei Kristen N. Peck Natalie Shih Ara A. Chalian Bert W. O’Malley Gregory S. Weinstein Michael D. Feldman James Alwine Erle S. Robertson Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
description	Abstract The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing to establish microbial signatures unique to human oral and oropharyngeal squamous cell carcinomas (OCSCC/OPSCC). Signatures for DNA and RNA viruses including oncogenic viruses, gram positive and negative bacteria, fungi and parasites were detected. Cluster and topological analyses identified 2 distinct groups of microbial signatures related to OCSCCs/OPSCCs. Results were validated by probe capture next generation sequencing; the data from which also provided a comprehensive map of integration sites and chromosomal hotspots for micro-organism genomic insertions. Identification of these microbial signatures and their integration sites may provide biomarkers for OCSCC/OPSCC diagnosis and prognosis as well as novel avenues for study of their potential role in OCSCCs/OPSCCs.
format	article
author	Sagarika Banerjee Tian Tian Zhi Wei Kristen N. Peck Natalie Shih Ara A. Chalian Bert W. O’Malley Gregory S. Weinstein Michael D. Feldman James Alwine Erle S. Robertson
author_facet	Sagarika Banerjee Tian Tian Zhi Wei Kristen N. Peck Natalie Shih Ara A. Chalian Bert W. O’Malley Gregory S. Weinstein Michael D. Feldman James Alwine Erle S. Robertson
author_sort	Sagarika Banerjee
title	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
title_short	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
title_full	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
title_fullStr	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
title_full_unstemmed	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
title_sort	microbial signatures associated with oropharyngeal and oral squamous cell carcinomas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6fcde7e76e04af0b25047f7738c8835
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Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas

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