Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections

Over the past decades, pan-resistant strains of major bacterial pathogens have emerged and have rendered clinically available antibiotics ineffective, putting at risk many of the major achievements of modern medicine, including surgery, cancer therapy, and organ transplantation. A thorough understa...

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Autores principales:	Isabella Santi, Pablo Manfredi, Enea Maffei, Adrian Egli, Urs Jenal
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a6fef537dc8b46d0bf00bdda74edefa0
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spelling	oai:doaj.org-article:a6fef537dc8b46d0bf00bdda74edefa02021-11-03T18:15:38ZEvolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections2161-21292150-751110.1128/mBio.03482-20https://doaj.org/article/a6fef537dc8b46d0bf00bdda74edefa02021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03482-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Over the past decades, pan-resistant strains of major bacterial pathogens have emerged and have rendered clinically available antibiotics ineffective, putting at risk many of the major achievements of modern medicine, including surgery, cancer therapy, and organ transplantation. A thorough understanding of processes leading to the development of antibiotic resistance in human patients is thus urgently needed.Isabella SantiPablo ManfrediEnea MaffeiAdrian EgliUrs JenalAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Isabella Santi Pablo Manfredi Enea Maffei Adrian Egli Urs Jenal Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
description	Over the past decades, pan-resistant strains of major bacterial pathogens have emerged and have rendered clinically available antibiotics ineffective, putting at risk many of the major achievements of modern medicine, including surgery, cancer therapy, and organ transplantation. A thorough understanding of processes leading to the development of antibiotic resistance in human patients is thus urgently needed.
format	article
author	Isabella Santi Pablo Manfredi Enea Maffei Adrian Egli Urs Jenal
author_facet	Isabella Santi Pablo Manfredi Enea Maffei Adrian Egli Urs Jenal
author_sort	Isabella Santi
title	Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
title_short	Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
title_full	Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
title_fullStr	Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
title_full_unstemmed	Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
title_sort	evolution of antibiotic tolerance shapes resistance development in chronic pseudomonas aeruginosa infections
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/a6fef537dc8b46d0bf00bdda74edefa0
work_keys_str_mv	AT isabellasanti evolutionofantibiotictoleranceshapesresistancedevelopmentinchronicpseudomonasaeruginosainfections AT pablomanfredi evolutionofantibiotictoleranceshapesresistancedevelopmentinchronicpseudomonasaeruginosainfections AT eneamaffei evolutionofantibiotictoleranceshapesresistancedevelopmentinchronicpseudomonasaeruginosainfections AT adrianegli evolutionofantibiotictoleranceshapesresistancedevelopmentinchronicpseudomonasaeruginosainfections AT ursjenal evolutionofantibiotictoleranceshapesresistancedevelopmentinchronicpseudomonasaeruginosainfections
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Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections

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