Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Abstract The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic balance between oxidants and antioxidants. However, redox status in adolescents with obesity and anemia has not been investigated. This study investigated the association of erythrocyte GSH redox status (GSH, GSH:GS...

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Autores principales:	Dalal Alkazemi, Abdur Rahman, Banan Habra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a70140b6ff734497a304524f96e62cf1
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spelling	oai:doaj.org-article:a70140b6ff734497a304524f96e62cf12021-12-02T14:06:55ZAlterations in glutathione redox homeostasis among adolescents with obesity and anemia10.1038/s41598-021-82579-52045-2322https://doaj.org/article/a70140b6ff734497a304524f96e62cf12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82579-5https://doaj.org/toc/2045-2322Abstract The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic balance between oxidants and antioxidants. However, redox status in adolescents with obesity and anemia has not been investigated. This study investigated the association of erythrocyte GSH redox status (GSH, GSH:GSSG ratio, and glutathione peroxidase [GPx] activity) with anemia and adiposity in adolescents. This case–control study nested in a cross-sectional study enrolled 524 adolescents (268 boys; 256 girls). The prevalence of anemia in overweight and obesity (OWOB) was 5.2% in boys and 11.7% in girls. The GSH:GSSG ratio and GPx activity were significantly higher in girls than in boys (p < 0.001), in anemic than in non-anemic subjects (p < 0.001), and in OWOB than in normal-weight subjects (p < 0.001). Similarly, significantly higher GSH: GSSG level (p < 0.001) and GPx activity (p < 0.001) were found in subjects with 90th percentile waist circumference than in those with < 90th percentile. GPx and GSH:GSSG were positively associated with anemia after adjusting for age, sex, and body mass index (adjusted odds ratio, adjOR [95% confidence interval, CI] 2.18 [1.44–3.29]) or tertiles (adjOR [95% CI], T3 = 2.49 [1.03–6.01]). A similar association was noted for GSH and GPx. A compensatory increased redox defense mechanism exists in anemia and obesity among adolescents without metabolic disturbances.Dalal AlkazemiAbdur RahmanBanan HabraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dalal Alkazemi Abdur Rahman Banan Habra Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
description	Abstract The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic balance between oxidants and antioxidants. However, redox status in adolescents with obesity and anemia has not been investigated. This study investigated the association of erythrocyte GSH redox status (GSH, GSH:GSSG ratio, and glutathione peroxidase [GPx] activity) with anemia and adiposity in adolescents. This case–control study nested in a cross-sectional study enrolled 524 adolescents (268 boys; 256 girls). The prevalence of anemia in overweight and obesity (OWOB) was 5.2% in boys and 11.7% in girls. The GSH:GSSG ratio and GPx activity were significantly higher in girls than in boys (p < 0.001), in anemic than in non-anemic subjects (p < 0.001), and in OWOB than in normal-weight subjects (p < 0.001). Similarly, significantly higher GSH: GSSG level (p < 0.001) and GPx activity (p < 0.001) were found in subjects with 90th percentile waist circumference than in those with < 90th percentile. GPx and GSH:GSSG were positively associated with anemia after adjusting for age, sex, and body mass index (adjusted odds ratio, adjOR [95% confidence interval, CI] 2.18 [1.44–3.29]) or tertiles (adjOR [95% CI], T3 = 2.49 [1.03–6.01]). A similar association was noted for GSH and GPx. A compensatory increased redox defense mechanism exists in anemia and obesity among adolescents without metabolic disturbances.
format	article
author	Dalal Alkazemi Abdur Rahman Banan Habra
author_facet	Dalal Alkazemi Abdur Rahman Banan Habra
author_sort	Dalal Alkazemi
title	Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
title_short	Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
title_full	Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
title_fullStr	Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
title_full_unstemmed	Alterations in glutathione redox homeostasis among adolescents with obesity and anemia
title_sort	alterations in glutathione redox homeostasis among adolescents with obesity and anemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a70140b6ff734497a304524f96e62cf1
work_keys_str_mv	AT dalalalkazemi alterationsinglutathioneredoxhomeostasisamongadolescentswithobesityandanemia AT abdurrahman alterationsinglutathioneredoxhomeostasisamongadolescentswithobesityandanemia AT bananhabra alterationsinglutathioneredoxhomeostasisamongadolescentswithobesityandanemia
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Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

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