Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study

Abstract External ventricular drainage (EVD) is an emergency neurosurgical procedure to decrease intracranial pressure through a catheter mediated drainage of cerebrospinal fluid. Most EVD catheters are placed using free hands without direct visualization of the target and catheter trajectory, leadi...

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Autores principales:	Abhijeet S. Barath, Aaron E. Rusheen, Juan M. Rojas Cabrera, Hojin Shin, Charles D. Blaha, Kevin E. Bennet, Stephan J. Goerss, Kendall H. Lee, Yoonbae Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a701fa0c4fe64c60b8055e012f78dc2c
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spelling	oai:doaj.org-article:a701fa0c4fe64c60b8055e012f78dc2c2021-12-02T16:38:49ZDevelopment and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study10.1038/s41598-021-97080-22045-2322https://doaj.org/article/a701fa0c4fe64c60b8055e012f78dc2c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97080-2https://doaj.org/toc/2045-2322Abstract External ventricular drainage (EVD) is an emergency neurosurgical procedure to decrease intracranial pressure through a catheter mediated drainage of cerebrospinal fluid. Most EVD catheters are placed using free hands without direct visualization of the target and catheter trajectory, leading to a high rate of complications- hemorrhage, brain injury and suboptimal catheter placement. Use of stereotactic systems can prevent these complications. However, they have found limited application for this procedure due to their long set-up time and expensive hardware. Therefore, we have developed and pre-clinically validated a novel 3D printed stereotactic system for rapid and accurate implantation of EVD catheters. Its mechanical and imaging accuracies were found to be at par with clinical stereotactic systems. Preclinical trial in human cadaver specimens revealed improved targeting accuracy achieved within an acceptable time frame compared to the free hand technique. CT angiography emulated using cadaver specimen with radio-opaque vascular contrast showed vessel free catheter trajectory. This could potentially translate to reduced hemorrhage rate. Thus, our 3D printed stereotactic system offers the potential to improve the accuracy and safety of EVD catheter placement for patients without significantly increasing the procedure time.Abhijeet S. BarathAaron E. RusheenJuan M. Rojas CabreraHojin ShinCharles D. BlahaKevin E. BennetStephan J. GoerssKendall H. LeeYoonbae OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abhijeet S. Barath Aaron E. Rusheen Juan M. Rojas Cabrera Hojin Shin Charles D. Blaha Kevin E. Bennet Stephan J. Goerss Kendall H. Lee Yoonbae Oh Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
description	Abstract External ventricular drainage (EVD) is an emergency neurosurgical procedure to decrease intracranial pressure through a catheter mediated drainage of cerebrospinal fluid. Most EVD catheters are placed using free hands without direct visualization of the target and catheter trajectory, leading to a high rate of complications- hemorrhage, brain injury and suboptimal catheter placement. Use of stereotactic systems can prevent these complications. However, they have found limited application for this procedure due to their long set-up time and expensive hardware. Therefore, we have developed and pre-clinically validated a novel 3D printed stereotactic system for rapid and accurate implantation of EVD catheters. Its mechanical and imaging accuracies were found to be at par with clinical stereotactic systems. Preclinical trial in human cadaver specimens revealed improved targeting accuracy achieved within an acceptable time frame compared to the free hand technique. CT angiography emulated using cadaver specimen with radio-opaque vascular contrast showed vessel free catheter trajectory. This could potentially translate to reduced hemorrhage rate. Thus, our 3D printed stereotactic system offers the potential to improve the accuracy and safety of EVD catheter placement for patients without significantly increasing the procedure time.
format	article
author	Abhijeet S. Barath Aaron E. Rusheen Juan M. Rojas Cabrera Hojin Shin Charles D. Blaha Kevin E. Bennet Stephan J. Goerss Kendall H. Lee Yoonbae Oh
author_facet	Abhijeet S. Barath Aaron E. Rusheen Juan M. Rojas Cabrera Hojin Shin Charles D. Blaha Kevin E. Bennet Stephan J. Goerss Kendall H. Lee Yoonbae Oh
author_sort	Abhijeet S. Barath
title	Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
title_short	Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
title_full	Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
title_fullStr	Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
title_full_unstemmed	Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
title_sort	development and validation of a rapidly deployable ct-guided stereotactic system for external ventricular drainage: preclinical study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a701fa0c4fe64c60b8055e012f78dc2c
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Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study

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