Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations tha...

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Autores principales: Bernard Pereira, Christopher T. Chen, Lipika Goyal, Charlotte Walmsley, Christopher J. Pinto, Islam Baiev, Read Allen, Laura Henderson, Supriya Saha, Stephanie Reyes, Martin S. Taylor, Donna M. Fitzgerald, Maida Williams Broudo, Avinash Sahu, Xin Gao, Wendy Winckler, A. Rose Brannon, Jeffrey A. Engelman, Rebecca Leary, James R. Stone, Catarina D. Campbell, Dejan Juric
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/a702ab2e73e84ce88013c89389a381ef
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Sumario:It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.

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