Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations tha...

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Autores principales:	Bernard Pereira, Christopher T. Chen, Lipika Goyal, Charlotte Walmsley, Christopher J. Pinto, Islam Baiev, Read Allen, Laura Henderson, Supriya Saha, Stephanie Reyes, Martin S. Taylor, Donna M. Fitzgerald, Maida Williams Broudo, Avinash Sahu, Xin Gao, Wendy Winckler, A. Rose Brannon, Jeffrey A. Engelman, Rebecca Leary, James R. Stone, Catarina D. Campbell, Dejan Juric
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a702ab2e73e84ce88013c89389a381ef
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spelling	oai:doaj.org-article:a702ab2e73e84ce88013c89389a381ef2021-12-02T14:47:29ZCell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer10.1038/s41467-021-23394-42041-1723https://doaj.org/article/a702ab2e73e84ce88013c89389a381ef2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23394-4https://doaj.org/toc/2041-1723It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.Bernard PereiraChristopher T. ChenLipika GoyalCharlotte WalmsleyChristopher J. PintoIslam BaievRead AllenLaura HendersonSupriya SahaStephanie ReyesMartin S. TaylorDonna M. FitzgeraldMaida Williams BroudoAvinash SahuXin GaoWendy WincklerA. Rose BrannonJeffrey A. EngelmanRebecca LearyJames R. StoneCatarina D. CampbellDejan JuricNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernard Pereira Christopher T. Chen Lipika Goyal Charlotte Walmsley Christopher J. Pinto Islam Baiev Read Allen Laura Henderson Supriya Saha Stephanie Reyes Martin S. Taylor Donna M. Fitzgerald Maida Williams Broudo Avinash Sahu Xin Gao Wendy Winckler A. Rose Brannon Jeffrey A. Engelman Rebecca Leary James R. Stone Catarina D. Campbell Dejan Juric Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
description	It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.
format	article
author	Bernard Pereira Christopher T. Chen Lipika Goyal Charlotte Walmsley Christopher J. Pinto Islam Baiev Read Allen Laura Henderson Supriya Saha Stephanie Reyes Martin S. Taylor Donna M. Fitzgerald Maida Williams Broudo Avinash Sahu Xin Gao Wendy Winckler A. Rose Brannon Jeffrey A. Engelman Rebecca Leary James R. Stone Catarina D. Campbell Dejan Juric
author_facet	Bernard Pereira Christopher T. Chen Lipika Goyal Charlotte Walmsley Christopher J. Pinto Islam Baiev Read Allen Laura Henderson Supriya Saha Stephanie Reyes Martin S. Taylor Donna M. Fitzgerald Maida Williams Broudo Avinash Sahu Xin Gao Wendy Winckler A. Rose Brannon Jeffrey A. Engelman Rebecca Leary James R. Stone Catarina D. Campbell Dejan Juric
author_sort	Bernard Pereira
title	Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
title_short	Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
title_full	Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
title_fullStr	Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
title_full_unstemmed	Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
title_sort	cell-free dna captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a702ab2e73e84ce88013c89389a381ef
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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

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