Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study

Abstract Caffeine is widely used to promote alertness and cognitive performance under challenging conditions, such as sleep loss. Non-digestive modes of delivery typically reduce variability of its effect. In a placebo-controlled, 50-h total sleep deprivation (TSD) protocol we administered four 200 ...

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Main Authors:	E. Aidman, M. Balin, K. Johnson, S. Jackson, G. M. Paech, M. Pajcin, C. Yates, E. Mitchelson, G. H. Kamimori, J. Fidock, C. Della Vedova, S. Banks
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/a703993afa3840b0b40defe30cdd2783
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spelling	oai:doaj.org-article:a703993afa3840b0b40defe30cdd27832021-12-02T10:54:24ZCaffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study10.1038/s41598-021-83504-62045-2322https://doaj.org/article/a703993afa3840b0b40defe30cdd27832021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83504-6https://doaj.org/toc/2045-2322Abstract Caffeine is widely used to promote alertness and cognitive performance under challenging conditions, such as sleep loss. Non-digestive modes of delivery typically reduce variability of its effect. In a placebo-controlled, 50-h total sleep deprivation (TSD) protocol we administered four 200 mg doses of caffeine-infused chewing-gum during night-time circadian trough and monitored participants' drowsiness during task performance with infra-red oculography. In addition to the expected reduction of sleepiness, caffeine was found to disrupt its degrading impact on performance errors in tasks ranging from standard cognitive tests to simulated driving. Real-time drowsiness data showed that caffeine produced only a modest reduction in sleepiness (compared to our placebo group) but substantial performance gains in vigilance and procedural decisions, that were largely independent of the actual alertness dynamics achieved. The magnitude of this disrupting effect was greater for more complex cognitive tasks.E. AidmanM. BalinK. JohnsonS. JacksonG. M. PaechM. PajcinC. YatesE. MitchelsonG. H. KamimoriJ. FidockC. Della VedovaS. BanksNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q E. Aidman M. Balin K. Johnson S. Jackson G. M. Paech M. Pajcin C. Yates E. Mitchelson G. H. Kamimori J. Fidock C. Della Vedova S. Banks Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
description	Abstract Caffeine is widely used to promote alertness and cognitive performance under challenging conditions, such as sleep loss. Non-digestive modes of delivery typically reduce variability of its effect. In a placebo-controlled, 50-h total sleep deprivation (TSD) protocol we administered four 200 mg doses of caffeine-infused chewing-gum during night-time circadian trough and monitored participants' drowsiness during task performance with infra-red oculography. In addition to the expected reduction of sleepiness, caffeine was found to disrupt its degrading impact on performance errors in tasks ranging from standard cognitive tests to simulated driving. Real-time drowsiness data showed that caffeine produced only a modest reduction in sleepiness (compared to our placebo group) but substantial performance gains in vigilance and procedural decisions, that were largely independent of the actual alertness dynamics achieved. The magnitude of this disrupting effect was greater for more complex cognitive tasks.
format	article
author	E. Aidman M. Balin K. Johnson S. Jackson G. M. Paech M. Pajcin C. Yates E. Mitchelson G. H. Kamimori J. Fidock C. Della Vedova S. Banks
author_facet	E. Aidman M. Balin K. Johnson S. Jackson G. M. Paech M. Pajcin C. Yates E. Mitchelson G. H. Kamimori J. Fidock C. Della Vedova S. Banks
author_sort	E. Aidman
title	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
title_short	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
title_full	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
title_fullStr	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
title_full_unstemmed	Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
title_sort	caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a703993afa3840b0b40defe30cdd2783
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Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study

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