Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?

Objective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). Patients and methods: A retrospective, cohort study was conducted using our institution’s data fr...

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Autores principales:	Onkar Singh, Thampi John Nirmal, Rajiv Paul Mukha, Gowri Mahasampath, J. Chandrasingh, Antony Devasia, Santosh Kumar, Nitin Sudhakar Kekre
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/a70705b956fa438487aefa159597d8a8
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spelling	oai:doaj.org-article:a70705b956fa438487aefa159597d8a82021-12-02T12:07:16ZPositive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?2090-598X10.1016/j.aju.2018.06.004https://doaj.org/article/a70705b956fa438487aefa159597d8a82018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18300639https://doaj.org/toc/2090-598XObjective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). Patients and methods: A retrospective, cohort study was conducted using our institution’s data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. In all, 211 patients underwent RC for UC during the study period. The patients were divided into two groups: Group-I (n = 17) with PUM and Group-II (n = 194) with negative ureteric margins. Univariate and multivariate analyses were performed to determine the predictors of PUM. Results: On univariate analysis, multifocality, tumours involving the ureteric orifice, trigonal tumours, presence of carcinoma in situ (CIS), and lymphovascular invasion at TURBT, were significantly more common in Group-I. On multivariate analysis, tumour involvement in the ureteric orifice(s) and presence of associated CIS significantly predicted PUM. Conclusions: Primary tumour-related factors on initial TURBT that predicted PUM (at RC) were involvement of the ureteric orifice(s) and presence of associated CIS. These results may help to select patients who can be selectively offered intraoperative frozen section analysis. Keywords: Bladder cancer, Treatment, Radical cystectomy, Surgical margin, Distal ureteric marginOnkar SinghThampi John NirmalRajiv Paul MukhaGowri MahasampathJ. ChandrasinghAntony DevasiaSantosh KumarNitin Sudhakar KekreTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 4, Pp 386-390 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Onkar Singh Thampi John Nirmal Rajiv Paul Mukha Gowri Mahasampath J. Chandrasingh Antony Devasia Santosh Kumar Nitin Sudhakar Kekre Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
description	Objective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC). Patients and methods: A retrospective, cohort study was conducted using our institution’s data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. In all, 211 patients underwent RC for UC during the study period. The patients were divided into two groups: Group-I (n = 17) with PUM and Group-II (n = 194) with negative ureteric margins. Univariate and multivariate analyses were performed to determine the predictors of PUM. Results: On univariate analysis, multifocality, tumours involving the ureteric orifice, trigonal tumours, presence of carcinoma in situ (CIS), and lymphovascular invasion at TURBT, were significantly more common in Group-I. On multivariate analysis, tumour involvement in the ureteric orifice(s) and presence of associated CIS significantly predicted PUM. Conclusions: Primary tumour-related factors on initial TURBT that predicted PUM (at RC) were involvement of the ureteric orifice(s) and presence of associated CIS. These results may help to select patients who can be selectively offered intraoperative frozen section analysis. Keywords: Bladder cancer, Treatment, Radical cystectomy, Surgical margin, Distal ureteric margin
format	article
author	Onkar Singh Thampi John Nirmal Rajiv Paul Mukha Gowri Mahasampath J. Chandrasingh Antony Devasia Santosh Kumar Nitin Sudhakar Kekre
author_facet	Onkar Singh Thampi John Nirmal Rajiv Paul Mukha Gowri Mahasampath J. Chandrasingh Antony Devasia Santosh Kumar Nitin Sudhakar Kekre
author_sort	Onkar Singh
title	Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
title_short	Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
title_full	Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
title_fullStr	Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
title_full_unstemmed	Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?
title_sort	positive ureteric margins at radical cystectomy: can it be predicted at initial transurethral resection of bladder tumour?
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/a70705b956fa438487aefa159597d8a8
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Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?

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