Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy

siRNA interference therapy can silence tumor cell target genes and specifically regulate tumor cell behavior and function, which is an effective antitumor therapy. However, in somatic circulation, naked siRNAs are not only susceptible to degrade, but it is also difficult to realize the tumor cells’...

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Autores principales:	Si Chen, Jiguang Li, Xiaoyu Ma, Fan Liu, Guoping Yan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gene therapy peptide siRNA carrier gold nanostars tumor targeting Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/a70a235ba144444d8db06a0775e07759
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spelling	oai:doaj.org-article:a70a235ba144444d8db06a0775e077592021-11-11T18:46:48ZCationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy10.3390/polym132137642073-4360https://doaj.org/article/a70a235ba144444d8db06a0775e077592021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3764https://doaj.org/toc/2073-4360siRNA interference therapy can silence tumor cell target genes and specifically regulate tumor cell behavior and function, which is an effective antitumor therapy. However, in somatic circulation, naked siRNAs are not only susceptible to degrade, but it is also difficult to realize the tumor cells’ internalization. Therefore, novel siRNA delivery vectors that could promote efficacy need to be developed urgently. Here, we designed high-surface gold nanostars (GNS-P) which are decorated with cationic tumor-targeting peptide as an efficient and functional siRNA delivery nanoplatform for tumor therapy. The positively charged amino acid sequence and huge surface area enabled the vector to load a large amount of siRNA, while the tumor-targeting peptide sequence and nano size enabled it to rapidly and precisely target the tumor regions for fast and effective siRNA delivery. This tumor-targeting nanoplatform, GNS-P, displayed good biocompatibility, low toxicity and an extraordinary tumor accumulation capability.Si ChenJiguang LiXiaoyu MaFan LiuGuoping YanMDPI AGarticlegene therapypeptidesiRNA carriergold nanostarstumor targetingOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3764, p 3764 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gene therapy peptide siRNA carrier gold nanostars tumor targeting Organic chemistry QD241-441
spellingShingle	gene therapy peptide siRNA carrier gold nanostars tumor targeting Organic chemistry QD241-441 Si Chen Jiguang Li Xiaoyu Ma Fan Liu Guoping Yan Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
description	siRNA interference therapy can silence tumor cell target genes and specifically regulate tumor cell behavior and function, which is an effective antitumor therapy. However, in somatic circulation, naked siRNAs are not only susceptible to degrade, but it is also difficult to realize the tumor cells’ internalization. Therefore, novel siRNA delivery vectors that could promote efficacy need to be developed urgently. Here, we designed high-surface gold nanostars (GNS-P) which are decorated with cationic tumor-targeting peptide as an efficient and functional siRNA delivery nanoplatform for tumor therapy. The positively charged amino acid sequence and huge surface area enabled the vector to load a large amount of siRNA, while the tumor-targeting peptide sequence and nano size enabled it to rapidly and precisely target the tumor regions for fast and effective siRNA delivery. This tumor-targeting nanoplatform, GNS-P, displayed good biocompatibility, low toxicity and an extraordinary tumor accumulation capability.
format	article
author	Si Chen Jiguang Li Xiaoyu Ma Fan Liu Guoping Yan
author_facet	Si Chen Jiguang Li Xiaoyu Ma Fan Liu Guoping Yan
author_sort	Si Chen
title	Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
title_short	Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
title_full	Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
title_fullStr	Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
title_full_unstemmed	Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy
title_sort	cationic peptide-modified gold nanostars as efficient delivery platform for rna interference antitumor therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a70a235ba144444d8db06a0775e07759
work_keys_str_mv	AT sichen cationicpeptidemodifiedgoldnanostarsasefficientdeliveryplatformforrnainterferenceantitumortherapy AT jiguangli cationicpeptidemodifiedgoldnanostarsasefficientdeliveryplatformforrnainterferenceantitumortherapy AT xiaoyuma cationicpeptidemodifiedgoldnanostarsasefficientdeliveryplatformforrnainterferenceantitumortherapy AT fanliu cationicpeptidemodifiedgoldnanostarsasefficientdeliveryplatformforrnainterferenceantitumortherapy AT guopingyan cationicpeptidemodifiedgoldnanostarsasefficientdeliveryplatformforrnainterferenceantitumortherapy
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Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy

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