Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in th...

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Autores principales:	Keisuke Takeda, Aoi Uda, Mikihiro Mitsubori, Shun Nagashima, Hiroko Iwasaki, Naoki Ito, Isshin Shiiba, Satoshi Ishido, Masaaki Matsuoka, Ryoko Inatome, Shigeru Yanagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a70a607b38ad4df6980d72a5853d8a14
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spelling	oai:doaj.org-article:a70a607b38ad4df6980d72a5853d8a142021-12-02T12:09:17ZMitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation10.1038/s42003-021-01720-22399-3642https://doaj.org/article/a70a607b38ad4df6980d72a5853d8a142021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01720-2https://doaj.org/toc/2399-3642Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease.Keisuke TakedaAoi UdaMikihiro MitsuboriShun NagashimaHiroko IwasakiNaoki ItoIsshin ShiibaSatoshi IshidoMasaaki MatsuokaRyoko InatomeShigeru YanagiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
description	Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease.
format	article
author	Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi
author_facet	Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi
author_sort	Keisuke Takeda
title	Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
title_short	Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
title_full	Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
title_fullStr	Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
title_full_unstemmed	Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
title_sort	mitochondrial ubiquitin ligase alleviates alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a70a607b38ad4df6980d72a5853d8a14
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Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

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