A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis

Objectives: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a life-threatening disease. The current study aimed to quantitatively assess the pulmonary high-resolution computed tomography (HRCT) images of MDA5+ DM-ILD by...

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Autores principales:	Wenwen Xu, Wanlong Wu, Yu Zheng, Zhiwei Chen, Xinwei Tao, Danting Zhang, Jiangfeng Zhao, Kaiwen Wang, Bingpeng Guo, Qun Luo, Qian Han, Yan Zhou, Shuang Ye
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anti-melanoma differentiation-associated gene 5 dermatomyositis interstitial lung disease prognosis radiomics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a70ada8cd9054a8a8f191cdcdaf647cb
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spelling	oai:doaj.org-article:a70ada8cd9054a8a8f191cdcdaf647cb2021-12-01T14:22:46ZA Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis2296-858X10.3389/fmed.2021.768052https://doaj.org/article/a70ada8cd9054a8a8f191cdcdaf647cb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.768052/fullhttps://doaj.org/toc/2296-858XObjectives: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a life-threatening disease. The current study aimed to quantitatively assess the pulmonary high-resolution computed tomography (HRCT) images of MDA5+ DM-ILD by applying the radiomics approach and establish a multidimensional risk prediction model for the 6-month mortality.Methods: This retrospective study was conducted in 228 patients from two centers, namely, a derivation cohort and a longitudinal internal validation cohort in Renji Hospital, as well as an external validation cohort in Guangzhou. The derivation cohort was randomly divided into training and testing sets. The primary outcome was 6-month all-cause mortality since the time of admission. Baseline pulmonary HRCT images were quantitatively analyzed by radiomics approach, and a radiomic score (Rad-score) was generated. Clinical predictors selected by univariable Cox regression were further incorporated with the Rad-score, to enhance the prediction performance of the final model (Rad-score plus model). In parallel, an idiopathic pulmonary fibrosis (IPF)-based visual CT score and ILD-GAP score were calculated as comparators.Results: The Rad-score was significantly associated with the 6-month mortality, outperformed the traditional visual score and ILD-GAP score. The Rad-score plus model was successfully developed to predict the 6-month mortality, with C-index values of 0.88 [95% confidence interval (CI), 0.79–0.96] in the training set (n = 121), 0.88 (95%CI, 0.71–1.0) in the testing set (n = 31), 0.83 (95%CI, 0.68–0.98) in the internal validation cohort (n = 44), and 0.84 (95%CI, 0.64–1.0) in the external validation cohort (n = 32).Conclusions: The radiomic feature was an independent and reliable prognostic predictor for MDA5+ DM-ILD.Wenwen XuWanlong WuYu ZhengZhiwei ChenXinwei TaoDanting ZhangJiangfeng ZhaoKaiwen WangBingpeng GuoQun LuoQian HanYan ZhouShuang YeFrontiers Media S.A.articleanti-melanoma differentiation-associated gene 5dermatomyositisinterstitial lung diseaseprognosisradiomicsMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-melanoma differentiation-associated gene 5 dermatomyositis interstitial lung disease prognosis radiomics Medicine (General) R5-920
spellingShingle	anti-melanoma differentiation-associated gene 5 dermatomyositis interstitial lung disease prognosis radiomics Medicine (General) R5-920 Wenwen Xu Wanlong Wu Yu Zheng Zhiwei Chen Xinwei Tao Danting Zhang Jiangfeng Zhao Kaiwen Wang Bingpeng Guo Qun Luo Qian Han Yan Zhou Shuang Ye A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
description	Objectives: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a life-threatening disease. The current study aimed to quantitatively assess the pulmonary high-resolution computed tomography (HRCT) images of MDA5+ DM-ILD by applying the radiomics approach and establish a multidimensional risk prediction model for the 6-month mortality.Methods: This retrospective study was conducted in 228 patients from two centers, namely, a derivation cohort and a longitudinal internal validation cohort in Renji Hospital, as well as an external validation cohort in Guangzhou. The derivation cohort was randomly divided into training and testing sets. The primary outcome was 6-month all-cause mortality since the time of admission. Baseline pulmonary HRCT images were quantitatively analyzed by radiomics approach, and a radiomic score (Rad-score) was generated. Clinical predictors selected by univariable Cox regression were further incorporated with the Rad-score, to enhance the prediction performance of the final model (Rad-score plus model). In parallel, an idiopathic pulmonary fibrosis (IPF)-based visual CT score and ILD-GAP score were calculated as comparators.Results: The Rad-score was significantly associated with the 6-month mortality, outperformed the traditional visual score and ILD-GAP score. The Rad-score plus model was successfully developed to predict the 6-month mortality, with C-index values of 0.88 [95% confidence interval (CI), 0.79–0.96] in the training set (n = 121), 0.88 (95%CI, 0.71–1.0) in the testing set (n = 31), 0.83 (95%CI, 0.68–0.98) in the internal validation cohort (n = 44), and 0.84 (95%CI, 0.64–1.0) in the external validation cohort (n = 32).Conclusions: The radiomic feature was an independent and reliable prognostic predictor for MDA5+ DM-ILD.
format	article
author	Wenwen Xu Wanlong Wu Yu Zheng Zhiwei Chen Xinwei Tao Danting Zhang Jiangfeng Zhao Kaiwen Wang Bingpeng Guo Qun Luo Qian Han Yan Zhou Shuang Ye
author_facet	Wenwen Xu Wanlong Wu Yu Zheng Zhiwei Chen Xinwei Tao Danting Zhang Jiangfeng Zhao Kaiwen Wang Bingpeng Guo Qun Luo Qian Han Yan Zhou Shuang Ye
author_sort	Wenwen Xu
title	A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
title_short	A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
title_full	A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
title_fullStr	A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
title_full_unstemmed	A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis
title_sort	computed tomography radiomics-based prediction model on interstitial lung disease in anti-mda5-positive dermatomyositis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a70ada8cd9054a8a8f191cdcdaf647cb
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A Computed Tomography Radiomics-Based Prediction Model on Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis

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