A RNA producing DNA hydrogel as a platform for a high performance RNA interference system

Interfering RNA have a range of therapeutic and research based applications, issues with delivery have made systems that make siRNA in situ of interest. Here, the author report on the creation of a DNA hydrogel with improved stability and transcription efficiency over plasmid DNA.

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Bibliographic Details
Main Authors: Jaejung Song, Minhyuk Lee, Taeyoung Kim, Jeongkyeong Na, Yebin Jung, Gyoo Yeol Jung, Sungjee Kim, Nokyoung Park
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/a70b1bfd43ec42caa1dab8e2a2d576ec
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Summary:Interfering RNA have a range of therapeutic and research based applications, issues with delivery have made systems that make siRNA in situ of interest. Here, the author report on the creation of a DNA hydrogel with improved stability and transcription efficiency over plasmid DNA.