Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a...

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Autores principales:	Pecenova L., Farkas Robert
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	nuclear receptors coactivators bhlh-pas family Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/a70e11984c8c441bafc063100b009c24
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spelling	oai:doaj.org-article:a70e11984c8c441bafc063100b009c242021-12-02T15:29:47ZMultiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family1336-032910.1515/enr-2016-0019https://doaj.org/article/a70e11984c8c441bafc063100b009c242016-07-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0019https://doaj.org/toc/1336-0329Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a large superfamily of transcription factors that participate virtually in every key biological process. They control various aspects of animal development, fertility, gametogenesis, and numerous metabolic pathways, and can be misregulated in many types of cancers. Their enormous functional plasticity, as transcription factors, relates in part to NR-mediated interactions with plethora of coregulatory proteins upon ligand binding to their ligand binding domains (LBD), or following covalent modification. Here, we review some general views of a specific group of NR coregulators, so-called nuclear receptor coactivators (NRCs) or steroid receptor coactivators (SRCs) and highlight some of their unique functions/roles, which are less extensively mentioned and discussed in other reviews. We also try to pinpoint few neglected moments in the cooperative action of SRCs, which may also indicate their variable roles in the hormone-independent signaling pathways.Pecenova L.Farkas RobertSciendoarticlenuclear receptorscoactivatorsbhlh-pas familyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 3, Pp 165-181 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	nuclear receptors coactivators bhlh-pas family Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	nuclear receptors coactivators bhlh-pas family Diseases of the endocrine glands. Clinical endocrinology RC648-665 Pecenova L. Farkas Robert Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
description	Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a large superfamily of transcription factors that participate virtually in every key biological process. They control various aspects of animal development, fertility, gametogenesis, and numerous metabolic pathways, and can be misregulated in many types of cancers. Their enormous functional plasticity, as transcription factors, relates in part to NR-mediated interactions with plethora of coregulatory proteins upon ligand binding to their ligand binding domains (LBD), or following covalent modification. Here, we review some general views of a specific group of NR coregulators, so-called nuclear receptor coactivators (NRCs) or steroid receptor coactivators (SRCs) and highlight some of their unique functions/roles, which are less extensively mentioned and discussed in other reviews. We also try to pinpoint few neglected moments in the cooperative action of SRCs, which may also indicate their variable roles in the hormone-independent signaling pathways.
format	article
author	Pecenova L. Farkas Robert
author_facet	Pecenova L. Farkas Robert
author_sort	Pecenova L.
title	Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
title_short	Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
title_full	Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
title_fullStr	Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
title_full_unstemmed	Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family
title_sort	multiple functions and essential roles of nuclear receptor coactivators of bhlh-pas family
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/a70e11984c8c441bafc063100b009c24
work_keys_str_mv	AT pecenoval multiplefunctionsandessentialrolesofnuclearreceptorcoactivatorsofbhlhpasfamily AT farkasrobert multiplefunctionsandessentialrolesofnuclearreceptorcoactivatorsofbhlhpasfamily
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Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

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