Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis

Abstract Conflicting evidence was found about the relationship between lipid profiles and R219K polymorphism in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. In this study, four meta-analyses were conducted to assess the effect of R219K on lipid levels, including high-density lip...

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Autores principales:	Zhangyan Shi, Yajie Tian, Ze Zhao, Yufei Wu, Xiuxia Hu, Junlin Li, Qianliang Chen, Yan Wang, Caiyan An, Kejin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a70e9ff61f4f4a5b82f7df2113d21e7c
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spelling	oai:doaj.org-article:a70e9ff61f4f4a5b82f7df2113d21e7c2021-11-08T10:53:22ZAssociation between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis10.1038/s41598-021-00961-92045-2322https://doaj.org/article/a70e9ff61f4f4a5b82f7df2113d21e7c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00961-9https://doaj.org/toc/2045-2322Abstract Conflicting evidence was found about the relationship between lipid profiles and R219K polymorphism in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. In this study, four meta-analyses were conducted to assess the effect of R219K on lipid levels, including high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, total cholesterol, and triglycerides (TG). A total of 125 samples of 87 studies (about 60,262 subjects) were included. The effect of each study was expressed using the standard mean difference (SMD) and 95% confidence interval (95% CI) and pooled by meta-analysis in the random-effects model. Subgroup and meta-regression analyses were conducted to explore potential heterogeneity sources. The overall pooled effect showed the following results. (1) The R219K was significantly associated with HDLC level (SMD = − 0.25 mmol/L, 95%CI − 0.32 to − 0.18, z = − 6.96, P < 0.01, recessive genetic model). People with different genotypes had significantly different HDLC levels under the recessive, codominant and dominant genetic models (all Ps < 0.01). (2) A weak and indeterminate relationship between R219K and TG level was observed (SMD = 0.18 mmol/L, 95%CI 0.06–0.30, z = 3.01, P < 0.01, recessive genetic model). These findings suggested that R219K was associated with HDLC and TG levels, which might implicate a promising clinical application for lipid-related disorders, though the influences of race, health status, BMI, and other heterogeneity sources should be considered when interpreting current findings. The protocol was registered at PROSPERO (registration number: CRD42021231178). Zhangyan ShiYajie TianZe ZhaoYufei WuXiuxia HuJunlin LiQianliang ChenYan WangCaiyan AnKejin ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhangyan Shi Yajie Tian Ze Zhao Yufei Wu Xiuxia Hu Junlin Li Qianliang Chen Yan Wang Caiyan An Kejin Zhang Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
description	Abstract Conflicting evidence was found about the relationship between lipid profiles and R219K polymorphism in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. In this study, four meta-analyses were conducted to assess the effect of R219K on lipid levels, including high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, total cholesterol, and triglycerides (TG). A total of 125 samples of 87 studies (about 60,262 subjects) were included. The effect of each study was expressed using the standard mean difference (SMD) and 95% confidence interval (95% CI) and pooled by meta-analysis in the random-effects model. Subgroup and meta-regression analyses were conducted to explore potential heterogeneity sources. The overall pooled effect showed the following results. (1) The R219K was significantly associated with HDLC level (SMD = − 0.25 mmol/L, 95%CI − 0.32 to − 0.18, z = − 6.96, P < 0.01, recessive genetic model). People with different genotypes had significantly different HDLC levels under the recessive, codominant and dominant genetic models (all Ps < 0.01). (2) A weak and indeterminate relationship between R219K and TG level was observed (SMD = 0.18 mmol/L, 95%CI 0.06–0.30, z = 3.01, P < 0.01, recessive genetic model). These findings suggested that R219K was associated with HDLC and TG levels, which might implicate a promising clinical application for lipid-related disorders, though the influences of race, health status, BMI, and other heterogeneity sources should be considered when interpreting current findings. The protocol was registered at PROSPERO (registration number: CRD42021231178).
format	article
author	Zhangyan Shi Yajie Tian Ze Zhao Yufei Wu Xiuxia Hu Junlin Li Qianliang Chen Yan Wang Caiyan An Kejin Zhang
author_facet	Zhangyan Shi Yajie Tian Ze Zhao Yufei Wu Xiuxia Hu Junlin Li Qianliang Chen Yan Wang Caiyan An Kejin Zhang
author_sort	Zhangyan Shi
title	Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
title_short	Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
title_full	Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
title_fullStr	Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
title_full_unstemmed	Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis
title_sort	association between the abca1 (r219k) polymorphism and lipid profiles: a meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a70e9ff61f4f4a5b82f7df2113d21e7c
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Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis

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