Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution

Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution

Abstract Hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (HDXMS) is a rapid and effective method for localizing and determining protein stability and dynamics. Localization is routinely limited to a peptide resolution of 5 to 20 amino acid residues. HDXMS data can contain informatio...

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Autores principales: Chris Gessner, Wieland Steinchen, Sabrina Bédard, John J. Skinner, Virgil L. Woods, Thomas J. Walsh, Gert Bange, Dionysios P. Pantazatos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a71050ed12c6431e8c2981c692e1ae08
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