Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance
The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesio...
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Nature Portfolio
2020
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oai:doaj.org-article:a712b17c7277429d9923c92438580cdd2021-12-02T15:34:33ZMutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance10.1038/s41467-020-14730-12041-1723https://doaj.org/article/a712b17c7277429d9923c92438580cdd2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14730-1https://doaj.org/toc/2041-1723The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.Bin ZhuYanzi XiaoMeredith YeagerGary CliffordNicolas WentzensenMichael CullenJoseph F. BolandSara BassMia K. SteinbergTina Raine-BennettDongHyuk LeeRobert D. BurkMaisa PinheiroLei SongMichael DeanChase W. NelsonLaurie BurdettKai YuDavid RobersonThomas LoreySilvia FranceschiPhilip E. CastleJoan WalkerRosemary ZunaMark SchiffmanLisa MirabelloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Bin Zhu Yanzi Xiao Meredith Yeager Gary Clifford Nicolas Wentzensen Michael Cullen Joseph F. Boland Sara Bass Mia K. Steinberg Tina Raine-Bennett DongHyuk Lee Robert D. Burk Maisa Pinheiro Lei Song Michael Dean Chase W. Nelson Laurie Burdett Kai Yu David Roberson Thomas Lorey Silvia Franceschi Philip E. Castle Joan Walker Rosemary Zuna Mark Schiffman Lisa Mirabello Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| description |
The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer. |
| format |
article |
| author |
Bin Zhu Yanzi Xiao Meredith Yeager Gary Clifford Nicolas Wentzensen Michael Cullen Joseph F. Boland Sara Bass Mia K. Steinberg Tina Raine-Bennett DongHyuk Lee Robert D. Burk Maisa Pinheiro Lei Song Michael Dean Chase W. Nelson Laurie Burdett Kai Yu David Roberson Thomas Lorey Silvia Franceschi Philip E. Castle Joan Walker Rosemary Zuna Mark Schiffman Lisa Mirabello |
| author_facet |
Bin Zhu Yanzi Xiao Meredith Yeager Gary Clifford Nicolas Wentzensen Michael Cullen Joseph F. Boland Sara Bass Mia K. Steinberg Tina Raine-Bennett DongHyuk Lee Robert D. Burk Maisa Pinheiro Lei Song Michael Dean Chase W. Nelson Laurie Burdett Kai Yu David Roberson Thomas Lorey Silvia Franceschi Philip E. Castle Joan Walker Rosemary Zuna Mark Schiffman Lisa Mirabello |
| author_sort |
Bin Zhu |
| title |
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| title_short |
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| title_full |
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| title_fullStr |
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| title_full_unstemmed |
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance |
| title_sort |
mutations in the hpv16 genome induced by apobec3 are associated with viral clearance |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a712b17c7277429d9923c92438580cdd |
| work_keys_str_mv |
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