Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesio...

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Autores principales: Bin Zhu, Yanzi Xiao, Meredith Yeager, Gary Clifford, Nicolas Wentzensen, Michael Cullen, Joseph F. Boland, Sara Bass, Mia K. Steinberg, Tina Raine-Bennett, DongHyuk Lee, Robert D. Burk, Maisa Pinheiro, Lei Song, Michael Dean, Chase W. Nelson, Laurie Burdett, Kai Yu, David Roberson, Thomas Lorey, Silvia Franceschi, Philip E. Castle, Joan Walker, Rosemary Zuna, Mark Schiffman, Lisa Mirabello
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/a712b17c7277429d9923c92438580cdd
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