BP180/Collagen XVII: A Molecular View

BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina...

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Autores principales:	Jussi Tuusa, Nina Kokkonen, Kaisa Tasanen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autoimmune disease bullous pemphigoid hemidesmosome intrinsically disordered keratinocyte protein–protein interaction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a712ee00d3df459ab190b6be5b095e4b
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id	oai:doaj.org-article:a712ee00d3df459ab190b6be5b095e4b
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spelling	oai:doaj.org-article:a712ee00d3df459ab190b6be5b095e4b2021-11-25T17:54:34ZBP180/Collagen XVII: A Molecular View10.3390/ijms2222122331422-00671661-6596https://doaj.org/article/a712ee00d3df459ab190b6be5b095e4b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12233https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina, but BP180 is also expressed in several non-HD locations, where its functions are poorly characterized. The immunological roles of intact and proteolytically processed BP180, relevant in BP, have been subject to intensive research, but novel functions in cell proliferation, differentiation, and aging have also recently been described. To better understand the multiple physiological functions of BP180, the focus should return to the protein itself. Here, we comprehensively review the properties of the BP180 molecule, present new data on the biochemical features of its intracellular domain, and discuss their significance with regard to BP180 folding and protein–protein interactions.Jussi TuusaNina KokkonenKaisa TasanenMDPI AGarticleautoimmune diseasebullous pemphigoidhemidesmosomeintrinsically disorderedkeratinocyteprotein–protein interactionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12233, p 12233 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune disease bullous pemphigoid hemidesmosome intrinsically disordered keratinocyte protein–protein interaction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	autoimmune disease bullous pemphigoid hemidesmosome intrinsically disordered keratinocyte protein–protein interaction Biology (General) QH301-705.5 Chemistry QD1-999 Jussi Tuusa Nina Kokkonen Kaisa Tasanen BP180/Collagen XVII: A Molecular View
description	BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina, but BP180 is also expressed in several non-HD locations, where its functions are poorly characterized. The immunological roles of intact and proteolytically processed BP180, relevant in BP, have been subject to intensive research, but novel functions in cell proliferation, differentiation, and aging have also recently been described. To better understand the multiple physiological functions of BP180, the focus should return to the protein itself. Here, we comprehensively review the properties of the BP180 molecule, present new data on the biochemical features of its intracellular domain, and discuss their significance with regard to BP180 folding and protein–protein interactions.
format	article
author	Jussi Tuusa Nina Kokkonen Kaisa Tasanen
author_facet	Jussi Tuusa Nina Kokkonen Kaisa Tasanen
author_sort	Jussi Tuusa
title	BP180/Collagen XVII: A Molecular View
title_short	BP180/Collagen XVII: A Molecular View
title_full	BP180/Collagen XVII: A Molecular View
title_fullStr	BP180/Collagen XVII: A Molecular View
title_full_unstemmed	BP180/Collagen XVII: A Molecular View
title_sort	bp180/collagen xvii: a molecular view
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a712ee00d3df459ab190b6be5b095e4b
work_keys_str_mv	AT jussituusa bp180collagenxviiamolecularview AT ninakokkonen bp180collagenxviiamolecularview AT kaisatasanen bp180collagenxviiamolecularview
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BP180/Collagen XVII: A Molecular View

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