A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.

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Autores principales:	Shirley L. Zhang, Nicholas F. Lahens, Zhifeng Yue, Denice M. Arnold, Peter P. Pakstis, Jessica E. Schwarz, Amita Sehgal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7136728c6604f689f9ba94c54ccf6b6
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spelling	oai:doaj.org-article:a7136728c6604f689f9ba94c54ccf6b62021-12-02T13:24:33ZA circadian clock regulates efflux by the blood-brain barrier in mice and human cells10.1038/s41467-020-20795-92041-1723https://doaj.org/article/a7136728c6604f689f9ba94c54ccf6b62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20795-9https://doaj.org/toc/2041-1723The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.Shirley L. ZhangNicholas F. LahensZhifeng YueDenice M. ArnoldPeter P. PakstisJessica E. SchwarzAmita SehgalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shirley L. Zhang Nicholas F. Lahens Zhifeng Yue Denice M. Arnold Peter P. Pakstis Jessica E. Schwarz Amita Sehgal A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
description	The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.
format	article
author	Shirley L. Zhang Nicholas F. Lahens Zhifeng Yue Denice M. Arnold Peter P. Pakstis Jessica E. Schwarz Amita Sehgal
author_facet	Shirley L. Zhang Nicholas F. Lahens Zhifeng Yue Denice M. Arnold Peter P. Pakstis Jessica E. Schwarz Amita Sehgal
author_sort	Shirley L. Zhang
title	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
title_short	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
title_full	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
title_fullStr	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
title_full_unstemmed	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
title_sort	circadian clock regulates efflux by the blood-brain barrier in mice and human cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7136728c6604f689f9ba94c54ccf6b6
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A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

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