Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation
Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community. The preservation of organs during this process from donor to recipient is critical to the prognosis of both th...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a71697e25cb8458aba9956b64b01a03e2021-12-01T19:24:47ZHemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation1663-981210.3389/fphar.2021.760215https://doaj.org/article/a71697e25cb8458aba9956b64b01a03e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.760215/fullhttps://doaj.org/toc/1663-9812Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community. The preservation of organs during this process from donor to recipient is critical to the prognosis of both the graft and the recipient. At present, static cold storage, which is most widely used in clinical practice, not only reduces cell metabolism and oxygen demand through low temperature but also prevents cell edema and resists apoptosis through the application of traditional preservation solutions, but these do not improve hypoxia and increase oxygenation of the donor organ. In recent years, improving the ischemia and hypoxia of grafts during preservation and repairing the quality of marginal donor organs have been of great concern. Hemoglobin-based oxygen carriers (HBOCs) are “made of” natural hemoglobins that were originally developed as blood substitutes but have been extended to a variety of hypoxic clinical situations due to their ability to release oxygen. Compared with traditional preservation protocols, the addition of HBOCs to traditional preservation protocols provides more oxygen to organs to meet their energy metabolic needs, prolong preservation time, reduce ischemia–reperfusion injury to grafts, improve graft quality, and even increase the number of transplantable donors. The focus of the present study was to review the potential applications of HBOCs in solid organ preservation and provide new approaches to understanding the mechanism of the promising strategies for organ preservation.Min CaoGuoqing WangHongli HeRuiming YueYong ZhaoLingai PanWeiwei HuangYang GuoTao YinLina MaDingding ZhangXiaobo HuangFrontiers Media S.A.articlehemoglobin-based oxygen carrierssolid organ preservationmachine perfusionorgan oxygenationischemia–reperfusion injuryTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
hemoglobin-based oxygen carriers solid organ preservation machine perfusion organ oxygenation ischemia–reperfusion injury Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
hemoglobin-based oxygen carriers solid organ preservation machine perfusion organ oxygenation ischemia–reperfusion injury Therapeutics. Pharmacology RM1-950 Min Cao Guoqing Wang Hongli He Ruiming Yue Yong Zhao Lingai Pan Weiwei Huang Yang Guo Tao Yin Lina Ma Dingding Zhang Xiaobo Huang Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| description |
Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community. The preservation of organs during this process from donor to recipient is critical to the prognosis of both the graft and the recipient. At present, static cold storage, which is most widely used in clinical practice, not only reduces cell metabolism and oxygen demand through low temperature but also prevents cell edema and resists apoptosis through the application of traditional preservation solutions, but these do not improve hypoxia and increase oxygenation of the donor organ. In recent years, improving the ischemia and hypoxia of grafts during preservation and repairing the quality of marginal donor organs have been of great concern. Hemoglobin-based oxygen carriers (HBOCs) are “made of” natural hemoglobins that were originally developed as blood substitutes but have been extended to a variety of hypoxic clinical situations due to their ability to release oxygen. Compared with traditional preservation protocols, the addition of HBOCs to traditional preservation protocols provides more oxygen to organs to meet their energy metabolic needs, prolong preservation time, reduce ischemia–reperfusion injury to grafts, improve graft quality, and even increase the number of transplantable donors. The focus of the present study was to review the potential applications of HBOCs in solid organ preservation and provide new approaches to understanding the mechanism of the promising strategies for organ preservation. |
| format |
article |
| author |
Min Cao Guoqing Wang Hongli He Ruiming Yue Yong Zhao Lingai Pan Weiwei Huang Yang Guo Tao Yin Lina Ma Dingding Zhang Xiaobo Huang |
| author_facet |
Min Cao Guoqing Wang Hongli He Ruiming Yue Yong Zhao Lingai Pan Weiwei Huang Yang Guo Tao Yin Lina Ma Dingding Zhang Xiaobo Huang |
| author_sort |
Min Cao |
| title |
Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| title_short |
Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| title_full |
Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| title_fullStr |
Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| title_full_unstemmed |
Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation |
| title_sort |
hemoglobin-based oxygen carriers: potential applications in solid organ preservation |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a71697e25cb8458aba9956b64b01a03e |
| work_keys_str_mv |
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| _version_ |
1718404647800012800 |