Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages o...

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Autores principales:	Beth Lucas, Andrea J. White, Emilie J. Cosway, Sonia M. Parnell, Kieran D. James, Nick D. Jones, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Graham Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a71a0ce69050482687895e76227ecd62
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spelling	oai:doaj.org-article:a71a0ce69050482687895e76227ecd622021-12-02T15:39:21ZDiversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells10.1038/s41467-020-16041-x2041-1723https://doaj.org/article/a71a0ce69050482687895e76227ecd622020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16041-xhttps://doaj.org/toc/2041-1723Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.Beth LucasAndrea J. WhiteEmilie J. CoswaySonia M. ParnellKieran D. JamesNick D. JonesIzumi OhigashiYousuke TakahamaWilliam E. JenkinsonGraham AndersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beth Lucas Andrea J. White Emilie J. Cosway Sonia M. Parnell Kieran D. James Nick D. Jones Izumi Ohigashi Yousuke Takahama William E. Jenkinson Graham Anderson Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
description	Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.
format	article
author	Beth Lucas Andrea J. White Emilie J. Cosway Sonia M. Parnell Kieran D. James Nick D. Jones Izumi Ohigashi Yousuke Takahama William E. Jenkinson Graham Anderson
author_facet	Beth Lucas Andrea J. White Emilie J. Cosway Sonia M. Parnell Kieran D. James Nick D. Jones Izumi Ohigashi Yousuke Takahama William E. Jenkinson Graham Anderson
author_sort	Beth Lucas
title	Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
title_short	Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
title_full	Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
title_fullStr	Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
title_full_unstemmed	Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
title_sort	diversity in medullary thymic epithelial cells controls the activity and availability of inkt cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a71a0ce69050482687895e76227ecd62
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Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

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