Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.

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Autores principales:	Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a71c12caa26f44d78217562e8216d63b
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spelling	oai:doaj.org-article:a71c12caa26f44d78217562e8216d63b2021-12-02T14:35:39ZIdentification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells10.1038/s41467-021-23003-42041-1723https://doaj.org/article/a71c12caa26f44d78217562e8216d63b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23003-4https://doaj.org/toc/2041-1723Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.Junji XingAo ZhangYong DuMingli FangLaurie J. MinzeYong-Jun LiuXian Chang LiZhiqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junji Xing Ao Zhang Yong Du Mingli Fang Laurie J. Minze Yong-Jun Liu Xian Chang Li Zhiqiang Zhang Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
description	Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.
format	article
author	Junji Xing Ao Zhang Yong Du Mingli Fang Laurie J. Minze Yong-Jun Liu Xian Chang Li Zhiqiang Zhang
author_facet	Junji Xing Ao Zhang Yong Du Mingli Fang Laurie J. Minze Yong-Jun Liu Xian Chang Li Zhiqiang Zhang
author_sort	Junji Xing
title	Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
title_short	Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
title_full	Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
title_fullStr	Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
title_full_unstemmed	Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
title_sort	identification of poly(adp-ribose) polymerase 9 (parp9) as a noncanonical sensor for rna virus in dendritic cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a71c12caa26f44d78217562e8216d63b
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Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

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