Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.

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Autores principales: Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a71c12caa26f44d78217562e8216d63b
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