Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

Necrotizing soft tissue infections (NSTIs) are caused by a single pathogen such as Streptococcus pyogenes or by multiple bacterial species. Here, the authors integrate microbial community profiling with host and pathogen transcriptional analysis in patient biopsies, and identify an interferon-relate...

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Autores principales:	Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun, Anna Norrby-Teglund, INFECT study group, Eva Medina, Dietmar H. Pieper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a71db1a3f33741e88b0fff82cb740d6b
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spelling	oai:doaj.org-article:a71db1a3f33741e88b0fff82cb740d6b2021-12-02T16:57:33ZMolecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections10.1038/s41467-019-11722-82041-1723https://doaj.org/article/a71db1a3f33741e88b0fff82cb740d6b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11722-8https://doaj.org/toc/2041-1723Necrotizing soft tissue infections (NSTIs) are caused by a single pathogen such as Streptococcus pyogenes or by multiple bacterial species. Here, the authors integrate microbial community profiling with host and pathogen transcriptional analysis in patient biopsies, and identify an interferon-related signature specific to S. pyogenes NSTIs.Robert ThänertAndreas ItzekJörn HoßmannDomenica HamischMartin Bruun MadsenOle HyldegaardSteinar SkredeTrond BruunAnna Norrby-TeglundINFECT study groupEva MedinaDietmar H. PieperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert Thänert Andreas Itzek Jörn Hoßmann Domenica Hamisch Martin Bruun Madsen Ole Hyldegaard Steinar Skrede Trond Bruun Anna Norrby-Teglund INFECT study group Eva Medina Dietmar H. Pieper Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
description	Necrotizing soft tissue infections (NSTIs) are caused by a single pathogen such as Streptococcus pyogenes or by multiple bacterial species. Here, the authors integrate microbial community profiling with host and pathogen transcriptional analysis in patient biopsies, and identify an interferon-related signature specific to S. pyogenes NSTIs.
format	article
author	Robert Thänert Andreas Itzek Jörn Hoßmann Domenica Hamisch Martin Bruun Madsen Ole Hyldegaard Steinar Skrede Trond Bruun Anna Norrby-Teglund INFECT study group Eva Medina Dietmar H. Pieper
author_facet	Robert Thänert Andreas Itzek Jörn Hoßmann Domenica Hamisch Martin Bruun Madsen Ole Hyldegaard Steinar Skrede Trond Bruun Anna Norrby-Teglund INFECT study group Eva Medina Dietmar H. Pieper
author_sort	Robert Thänert
title	Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
title_short	Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
title_full	Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
title_fullStr	Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
title_full_unstemmed	Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
title_sort	molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a71db1a3f33741e88b0fff82cb740d6b
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Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

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