Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening

Abstract This paper demonstrates the design, synthesis, simulation, and testing of three distinct geometries of plasmonic gold nanoparticles for on-chip DNA screening towards liquid biopsy. By employing a seed-mediated growth method, we have synthesized gold nanospheres, nanorods, and nanobipyramids...

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Autores principales:	Amogha Tadimety, Ziqian Wu, John H. Molinski, Russell Beckerman, Congran Jin, Lauren Zhang, Timothy J. Palinski, John X. J. Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a72440af4ecf4005bc860c43fe105cc9
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spelling	oai:doaj.org-article:a72440af4ecf4005bc860c43fe105cc92021-12-02T15:23:08ZRational design of on-chip gold plasmonic nanoparticles towards ctDNA screening10.1038/s41598-021-93207-72045-2322https://doaj.org/article/a72440af4ecf4005bc860c43fe105cc92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93207-7https://doaj.org/toc/2045-2322Abstract This paper demonstrates the design, synthesis, simulation, and testing of three distinct geometries of plasmonic gold nanoparticles for on-chip DNA screening towards liquid biopsy. By employing a seed-mediated growth method, we have synthesized gold nanospheres, nanorods, and nanobipyramids. In parallel, we developed numerical simulations to understand the effects of nanoparticle geometry on the resonance features and refractive index sensitivity. Both experimental and simulation results were compared through a series of studies including in-solution and on-chip tests. We have thoroughly characterized the impact of nanoparticle geometry on the sensitivity to circulating tumor DNA, with immediate implications for liquid biopsy. The results agree well with theoretical predictions and simulations, including both bulk refractive index sensitivity and thin film sensitivity. Importantly, this work quantitatively establishes the link between nanoparticle geometry and efficacy in detecting rare circulating biomarkers. The nanobipyramids provided the highest sensitivity, approximately doubling the sensitivity compared to nanorods. To the best of our knowledge this is the first report carrying through geometric effects of simulation to clinically relevant biosensing. We put forth here synthesis and testing of three nanoparticle geometries, and a framework for both experimental and theoretical validation of plasmonic sensitivities towards liquid biopsy.Amogha TadimetyZiqian WuJohn H. MolinskiRussell BeckermanCongran JinLauren ZhangTimothy J. PalinskiJohn X. J. ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amogha Tadimety Ziqian Wu John H. Molinski Russell Beckerman Congran Jin Lauren Zhang Timothy J. Palinski John X. J. Zhang Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
description	Abstract This paper demonstrates the design, synthesis, simulation, and testing of three distinct geometries of plasmonic gold nanoparticles for on-chip DNA screening towards liquid biopsy. By employing a seed-mediated growth method, we have synthesized gold nanospheres, nanorods, and nanobipyramids. In parallel, we developed numerical simulations to understand the effects of nanoparticle geometry on the resonance features and refractive index sensitivity. Both experimental and simulation results were compared through a series of studies including in-solution and on-chip tests. We have thoroughly characterized the impact of nanoparticle geometry on the sensitivity to circulating tumor DNA, with immediate implications for liquid biopsy. The results agree well with theoretical predictions and simulations, including both bulk refractive index sensitivity and thin film sensitivity. Importantly, this work quantitatively establishes the link between nanoparticle geometry and efficacy in detecting rare circulating biomarkers. The nanobipyramids provided the highest sensitivity, approximately doubling the sensitivity compared to nanorods. To the best of our knowledge this is the first report carrying through geometric effects of simulation to clinically relevant biosensing. We put forth here synthesis and testing of three nanoparticle geometries, and a framework for both experimental and theoretical validation of plasmonic sensitivities towards liquid biopsy.
format	article
author	Amogha Tadimety Ziqian Wu John H. Molinski Russell Beckerman Congran Jin Lauren Zhang Timothy J. Palinski John X. J. Zhang
author_facet	Amogha Tadimety Ziqian Wu John H. Molinski Russell Beckerman Congran Jin Lauren Zhang Timothy J. Palinski John X. J. Zhang
author_sort	Amogha Tadimety
title	Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
title_short	Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
title_full	Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
title_fullStr	Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
title_full_unstemmed	Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening
title_sort	rational design of on-chip gold plasmonic nanoparticles towards ctdna screening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a72440af4ecf4005bc860c43fe105cc9
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Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening

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