Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.

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Autores principales: Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. de Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer, Chris J. Janse, Susheel K. Singh, Michael Theisen, Phil Felgner, Matthias Marti, Chris Drakeley, Robert Sauerwein, Teun Bousema, Matthijs M. Jore
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a727fd054ca84e01a19890f2a0ecb7bd
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spelling oai:doaj.org-article:a727fd054ca84e01a19890f2a0ecb7bd2021-12-02T15:33:36ZUnravelling the immune signature of Plasmodium falciparum transmission-reducing immunity10.1038/s41467-017-02646-22041-1723https://doaj.org/article/a727fd054ca84e01a19890f2a0ecb7bd2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02646-2https://doaj.org/toc/2041-1723Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.Will J. R. StoneJoseph J. CampoAndré Lin OuédraogoLisette Meerstein-KesselIsabelle MorlaisDari DaAnna CohuetSandrine NsangoColin J. SutherlandMarga van de Vegte-BolmerRianne Siebelink-StoterGeert-Jan van GemertWouter GraumansKjerstin LankeAdam D. ShandlingJozelyn V. PabloAndy A. TengSophie JonesRoos M. de JongAmanda Fabra-GarcíaJohn BradleyWill RoeffenEdwin LasonderGiuliana GremoEvelin SchwarzerChris J. JanseSusheel K. SinghMichael TheisenPhil FelgnerMatthias MartiChris DrakeleyRobert SauerweinTeun BousemaMatthijs M. JoreNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Will J. R. Stone
Joseph J. Campo
André Lin Ouédraogo
Lisette Meerstein-Kessel
Isabelle Morlais
Dari Da
Anna Cohuet
Sandrine Nsango
Colin J. Sutherland
Marga van de Vegte-Bolmer
Rianne Siebelink-Stoter
Geert-Jan van Gemert
Wouter Graumans
Kjerstin Lanke
Adam D. Shandling
Jozelyn V. Pablo
Andy A. Teng
Sophie Jones
Roos M. de Jong
Amanda Fabra-García
John Bradley
Will Roeffen
Edwin Lasonder
Giuliana Gremo
Evelin Schwarzer
Chris J. Janse
Susheel K. Singh
Michael Theisen
Phil Felgner
Matthias Marti
Chris Drakeley
Robert Sauerwein
Teun Bousema
Matthijs M. Jore
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
description Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.
format article
author Will J. R. Stone
Joseph J. Campo
André Lin Ouédraogo
Lisette Meerstein-Kessel
Isabelle Morlais
Dari Da
Anna Cohuet
Sandrine Nsango
Colin J. Sutherland
Marga van de Vegte-Bolmer
Rianne Siebelink-Stoter
Geert-Jan van Gemert
Wouter Graumans
Kjerstin Lanke
Adam D. Shandling
Jozelyn V. Pablo
Andy A. Teng
Sophie Jones
Roos M. de Jong
Amanda Fabra-García
John Bradley
Will Roeffen
Edwin Lasonder
Giuliana Gremo
Evelin Schwarzer
Chris J. Janse
Susheel K. Singh
Michael Theisen
Phil Felgner
Matthias Marti
Chris Drakeley
Robert Sauerwein
Teun Bousema
Matthijs M. Jore
author_facet Will J. R. Stone
Joseph J. Campo
André Lin Ouédraogo
Lisette Meerstein-Kessel
Isabelle Morlais
Dari Da
Anna Cohuet
Sandrine Nsango
Colin J. Sutherland
Marga van de Vegte-Bolmer
Rianne Siebelink-Stoter
Geert-Jan van Gemert
Wouter Graumans
Kjerstin Lanke
Adam D. Shandling
Jozelyn V. Pablo
Andy A. Teng
Sophie Jones
Roos M. de Jong
Amanda Fabra-García
John Bradley
Will Roeffen
Edwin Lasonder
Giuliana Gremo
Evelin Schwarzer
Chris J. Janse
Susheel K. Singh
Michael Theisen
Phil Felgner
Matthias Marti
Chris Drakeley
Robert Sauerwein
Teun Bousema
Matthijs M. Jore
author_sort Will J. R. Stone
title Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
title_short Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
title_full Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
title_fullStr Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
title_full_unstemmed Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
title_sort unravelling the immune signature of plasmodium falciparum transmission-reducing immunity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a727fd054ca84e01a19890f2a0ecb7bd
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