Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta...

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Autores principales:	Christos Karampelias, Habib Rezanejad, Mandy Rosko, Likun Duan, Jing Lu, Laura Pazzagli, Philippe Bertolino, Carolyn E. Cesta, Xiaojing Liu, Gregory S. Korbutt, Olov Andersson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a728a4a3f5614b2a9d19997422e58055
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spelling	oai:doaj.org-article:a728a4a3f5614b2a9d19997422e580552021-12-02T17:34:29ZReinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation10.1038/s41467-021-23673-02041-1723https://doaj.org/article/a728a4a3f5614b2a9d19997422e580552021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23673-0https://doaj.org/toc/2041-1723Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.Christos KarampeliasHabib RezanejadMandy RoskoLikun DuanJing LuLaura PazzagliPhilippe BertolinoCarolyn E. CestaXiaojing LiuGregory S. KorbuttOlov AnderssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
description	Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.
format	article
author	Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson
author_facet	Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson
author_sort	Christos Karampelias
title	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_short	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_full	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_fullStr	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_full_unstemmed	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_sort	reinforcing one-carbon metabolism via folic acid/folr1 promotes β-cell differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a728a4a3f5614b2a9d19997422e58055
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Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

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