Hyponatremia and Oxidative Stress

Hyponatremia, i.e., the presence of a serum sodium concentration ([Na<sup>+</sup>]) < 136 mEq/L, is the most frequent electrolyte imbalance in the elderly and in hospitalized patients. Symptoms of acute hyponatremia, whose main target is the central nervous system, are explained by th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benedetta Fibbi, Giada Marroncini, Cecilia Anceschi, Laura Naldi, Alessandro Peri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyponatremia osmotic stress oxidative stress ROS senescence cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a72b27d94b104ca39ff47584009037c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a72b27d94b104ca39ff47584009037c7
record_format	dspace
spelling	oai:doaj.org-article:a72b27d94b104ca39ff47584009037c72021-11-25T16:28:04ZHyponatremia and Oxidative Stress10.3390/antiox101117682076-3921https://doaj.org/article/a72b27d94b104ca39ff47584009037c72021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1768https://doaj.org/toc/2076-3921Hyponatremia, i.e., the presence of a serum sodium concentration ([Na<sup>+</sup>]) < 136 mEq/L, is the most frequent electrolyte imbalance in the elderly and in hospitalized patients. Symptoms of acute hyponatremia, whose main target is the central nervous system, are explained by the “osmotic theory” and the neuronal swelling secondary to decreased extracellular osmolality, which determines cerebral oedema. Following the description of neurological and systemic manifestations even in mild and chronic hyponatremia, in the last decade reduced extracellular [Na<sup>+</sup>] was associated with detrimental effects on cellular homeostasis independently of hypoosmolality. Most of these alterations appeared to be elicited by oxidative stress. In this review, we focus on the role of oxidative stress on both osmolality-dependent and -independent impairment of cell and tissue functions observed in hyponatremic conditions. Furthermore, basic and clinical research suggested that oxidative stress appears to be a common denominator of the degenerative processes related to aging, cancer progression, and hyponatremia. Of note, low [Na<sup>+</sup>] is able to exacerbate multiple manifestations of senescence and to decrease progression-free and overall survival in oncologic patients.Benedetta FibbiGiada MarronciniCecilia AnceschiLaura NaldiAlessandro PeriMDPI AGarticlehyponatremiaosmotic stressoxidative stressROSsenescencecancerTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1768, p 1768 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyponatremia osmotic stress oxidative stress ROS senescence cancer Therapeutics. Pharmacology RM1-950
spellingShingle	hyponatremia osmotic stress oxidative stress ROS senescence cancer Therapeutics. Pharmacology RM1-950 Benedetta Fibbi Giada Marroncini Cecilia Anceschi Laura Naldi Alessandro Peri Hyponatremia and Oxidative Stress
description	Hyponatremia, i.e., the presence of a serum sodium concentration ([Na<sup>+</sup>]) < 136 mEq/L, is the most frequent electrolyte imbalance in the elderly and in hospitalized patients. Symptoms of acute hyponatremia, whose main target is the central nervous system, are explained by the “osmotic theory” and the neuronal swelling secondary to decreased extracellular osmolality, which determines cerebral oedema. Following the description of neurological and systemic manifestations even in mild and chronic hyponatremia, in the last decade reduced extracellular [Na<sup>+</sup>] was associated with detrimental effects on cellular homeostasis independently of hypoosmolality. Most of these alterations appeared to be elicited by oxidative stress. In this review, we focus on the role of oxidative stress on both osmolality-dependent and -independent impairment of cell and tissue functions observed in hyponatremic conditions. Furthermore, basic and clinical research suggested that oxidative stress appears to be a common denominator of the degenerative processes related to aging, cancer progression, and hyponatremia. Of note, low [Na<sup>+</sup>] is able to exacerbate multiple manifestations of senescence and to decrease progression-free and overall survival in oncologic patients.
format	article
author	Benedetta Fibbi Giada Marroncini Cecilia Anceschi Laura Naldi Alessandro Peri
author_facet	Benedetta Fibbi Giada Marroncini Cecilia Anceschi Laura Naldi Alessandro Peri
author_sort	Benedetta Fibbi
title	Hyponatremia and Oxidative Stress
title_short	Hyponatremia and Oxidative Stress
title_full	Hyponatremia and Oxidative Stress
title_fullStr	Hyponatremia and Oxidative Stress
title_full_unstemmed	Hyponatremia and Oxidative Stress
title_sort	hyponatremia and oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a72b27d94b104ca39ff47584009037c7
work_keys_str_mv	AT benedettafibbi hyponatremiaandoxidativestress AT giadamarroncini hyponatremiaandoxidativestress AT ceciliaanceschi hyponatremiaandoxidativestress AT lauranaldi hyponatremiaandoxidativestress AT alessandroperi hyponatremiaandoxidativestress
_version_	1718413157450383360

Hyponatremia and Oxidative Stress

Ejemplares similares